Daypro (Oxaprozin)

What is it?

Daypro is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen reduces inflammation, eases mild to moderate pain and reduces fever.

October 1992

Brand Names and International Availability:

Daypro; Deflam; Duraprox (U.S.), Deflam (South-Africa), Duraprox (Portugal)

How does it work?

As with most other nonsteroidal anti-inflammatory agents, its mode of action is not known. However, the ability to inhibit prostaglandin production is probably involved in the anti-inflammatory effect.


1200mg (2 600mg tabs) once a day.

How should I take it?

Oxaprozin can be taken with food to lessen stomach upset.


Those who have had a prior allergic reaction to other NSAIDs should not take Oxaprozin.

Oxaprozin should be avoided in those with a history of peptic ulcer or GI bleeding.

Oxaprozin should be used with caution in those with liver problems.

Oxaprozin should be used with caution in those with a history of heart problems, high blood pressure or fluid retention.

Oxaprozin is not recommended during pregnancy or in nursing mothers.

Safety and effectiveness of oxaprozin in children have not been established.

Drug Interactions:

Oxaprozin can increase the effect of anti-coagulants.

Oxaprozin should not be taken with any other NSAIDs.

Daypro may blunt the effectiveness of blood pressure medicines.

Because of the potent nature of this medicine, be sure to tell your doctor about any other medicines you are taking, including nonprescription medicines and vitamins.

Possible side effects:

These side effects are not considered serious but are certainly annoying for those experiencing them. The most frequently reported side effects include diarrhea or constipation, dizziness, drowsiness, gas, headache and nausea.

More serious side effects that you should report right away include blood in urine, black, tarry stools, chest pain or irregular heartbeat, difficulty breathing, skin rash, redness, blistering, peeling or itching, stomach pain or cramps, unusual bleeding or bruising, red spots on the skin, unusual tiredness or weakness, yellowing of the eyes or skin, ringing in the ears, swollen ankles or feet, vomit that looks like coffee grounds and any other unusual gastrointestinal symptoms.

Signs of a possible allergic reaction are rash, swelling and difficulty breathing. These symptoms should be reported immediately.

Precautions & Special Notes:

You will be required to have frequent blood work while on this medication. It is very important that you keep all lab and doctor’s appointments.

If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor at once. You may have a bleeding ulcer.

Some people become sensitive to sunlight while on Daypro, severe burns and rashes are possible. Use a strong sunscreen and avoid direct sunlight.

For more information:

RxList Daypro
Health Central Daypro