Diflunisal (Dolobid)

Diflunisal is a nonsteroidal antiinflammatory drug (NSAID). It reduces the joint pain, stiffness, inflammation, or swelling caused by rheumatoid arthritis and osteoarthritis. It also relieves mild to moderate pain.

FDA approved:

April 1992

Brand Names and International Availability:

Adomal (Italy); Analeric (Greece); Ansal (New-Zealand); Biartac (Belgium); Diflonid (Denmark, Norway, Sweden, Indonesia); Diflusal (Belgium); Difuton (Taiwan); Dolobid (US); Dolobis (France); Dolocid (Netherlands); Donobid (Finland, Denmark, Norway, Sweden); Dopanone; Dorbid (Brazil); Flovacil (Argentina); Flunidor (Portugal); Fluniget (Austria, Germany); Fluodonil; Ilacen (Taiwan); Noaldol; Reuflos (Italy); Unisal (Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, Switzerland)

How does it work?

The precise mechanism is not known. Diflunisal is a prostaglandin synthetase inhibitor. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues.


For osteoarthritis and rheumatoid arthritis, the suggested dosage range is 500 mg to 1000 mg daily in two divided doses.

How should I take it?

Take diflunisal as ordered, usually with food.


Contraindicated in those hypersensitive to other NSAIDs.

Diflunisal should be used with caution in patients with compromised cardiac function or hypertension.

Should be used with caution in those with kidney problems.

Diflunisal should be used during the first two trimesters of pregnancy only if the potential benefit justifies the potential risk to the fetus. Use during the third trimester of pregnancy is not recommended.

Use of the drug in children below the age of 12 years is not recommended.

Drug Interactions:

May increase the action of anti-coagulants.

Antacids may decrease the effectiveness of diflunisal.

Because of the potent nature of this medicine, be sure to tell your doctor about any other medicines you are taking, including nonprescription medicines and vitamins.

Possible side effects:

These side effects are not considered serious but are certainly annoying for those experiencing them. The most frequently reported side effects include constipation or diarrhea, dizziness, drowsiness, gas or heartburn, headache, nausea, vomiting, and insomnia.?

More serious side effects that you should report right away include dark yellow or brown urine, decrease in the amount of urine passed, difficulty breathing, fast heartbeat, ringing in the ears, skin rash, redness, blistering, peeling or itching swelling of eyelids, throat, lips or feet, unusual bleeding or bruising, and yellowing of eyes or skin.

Precautions & Special Notes:

If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor at once. You may have a bleeding ulcer.

For more information:

RxList Dolobid
MedicineNet Dolobid

Mosby’s GenRx?, 10th ed. Copyright ? 2000 Mosby, Inc.