Ibuprofen

What is Ibuprofen?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen reduces inflammation, eases mild to moderate pain and reduces fever.

FDA approved:

May 1985

Average annual cost:

$ 37.01 – 400 mg 3 per day

Brand Names and International Availability:

Act-3 (Australia, New-Zealand); Adex 200 (Israel); Advil (US); Alaxan; Algofen (Italy); Amersol (Canada); Am-Fam 400 (India); Anafen (New-Zealand); Anco (Germany); Andran (Japan); Anflagen (Japan); Antarene (France); Antiflam (South-Africa); Apo-Ibuprofen (Canada); Apsifen (England); Artofen (Israel); Artril; Atril 300 (Brazil); Balkaprofen (Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe); Betaprofen (South-Africa); Bloom; Bluton (Japan); Brofen; Brufanic (Japan); Brufen (Australia, New-Zealand; Austria, Belgium, Bulgaria, Czech-Republic, Denmark, England, Finland, France, Germany, Greece, Ireland, Italy, Netherlands, Norway, Portugal, Russia, Sweden, Switzerland, Turkey; Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates; Hong-Kong, Japan, Korea, Malaysia, Philippines, Taiwan, Thailand, South-Africa, New-Zealand); Brufen Retard (New-Zealand); Brufen 400 (Israel); Bruflam (Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates); Brufort (Italy); Buburone (Japan); Burana (Finland); Butacortelone (Mexico); Carol (Korea); Cobo (Korea); Codral Period Pain (Australia, New-Zealand); Combiflam (India); Dibufen (Mexico); Dolgit (Bahrain, Cyprus, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, Germany, Taiwan); Dolmaral (Colombia); Dolocyl (Switzerland); Dolofen; Dolofen-F (Indonesia); Dolomax (Peru); Donjust B (Japan); Dorival (Spain); Drin (Greece); Easifon (Taiwan); Ebufac (England); Emflam; Emflam-200 (India); Emodin (Argentina); Epobron (Japan); Fenbid (Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, South-Africa, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe; Bahrain, Cyprus, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, England); Fenspan; Focus (Italy); Gofen (Philippines); IB-100 (Japan); Ibosure (Netherlands); Ibren (US); Ibu-Tab (US); Ibufen (Israel, Malaysia, Thailand); Ibuflamar (India); Ibufug (Germany); Ibugen; Ibugesic (India); Ibulgan (Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, South-Africa, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe; Bahrain, Cyprus, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates; Bahamas, Barbados, Belize, Bermuda, Curacao, Guyana, Jamaica, Netherland-Antilles, Puerto-Rico, Surinam, Trinidad); Ibumetin (Denmark, Finland, Netherlands, Norway, Sweden); Ibupirac (Argentina); Ibuprocin (Japan); Ibuprofen (Hong-Kong); Ibuprohm (US); Ibusal (Finland); Ibu-slow (Belgium); Ifen (US); Imbun; Inabrin; Inflam; Inza (South-Africa); Ipren (Denmark, Russia, Sweden); Irfen (Bahrain, Cyprus, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, Switzerland); Isodol (Spain); Lamidon (Japan); Librofem (England, Spain); Lidifen (England); Liptan (Bahrain, Cyprus, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, Japan); Lopane (Thailand); Mensoton (Germany); Motrin (US); Motrin IB (New-Zealand); Mynosedin (Japan); Nagifen-D (Japan); Napacetin (Japan); Nobafon; Nobfelon (Japan); Nobgen (Japan); Noritis (Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, South-Africa, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe); Norton (South-Africa); Novogent (Germany); Novoprofen (Canada); Nurofen (Australia, New-Zealand; Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, South-Africa, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe, New-Zealand, Belgium, Denmark, Austria, Czech-Republic, England, France, Netherlands, Spain, Sweden, Turkey, Ireland); Optifen (Switzerland); Opturem (Germany); Ostarin (Indonesia); Ostofen (Thailand); Paduden; Panafen (New-Zealand); Pantrop (Japan); Paxofen; Perofen (Bahamas, Barbados, Belize, Bermuda, Curacao, Guyana, Jamaica, Netherland-Antilles, Puerto-Rico, Surinam, Trinidad, Malaysia); Proartinal (Mexico); Profen (US); Proflex (England); Provon (Peru); Quadrax (Mexico); Prontalgin; Rafen (Australia, New-Zealand); Ranofen (South-Africa); Relcofen (England); Roidenin (Japan); Rupan (Thailand); Stelar (Indonesia); Tabalon (Ecuador, India); Tabalon 400 (Mexico); Tarein; Tatanal (Korea); Tofen (Thailand); Uprofen (Taiwan); Urem (Germany); Zafen (Colombia); Zofen (Malaysia)

How does it work?

As with most other nonsteroidal anti-inflammatory agents, its mode of action is not known. However, the ability to inhibit prostaglandin production is probably involved in the anti-inflammatory effect.

Dosage:

1200-3200 mg daily in split doses is recommended for adults.

How should I take it?

Ibuprofen should be taken with food.

Contraindications:

Those who have had a prior allergic reaction to other NSAIDs should not take Ibuprofen.

Ibuprofen should be avoided in those with a history of peptic ulcer or GI bleeding.

Ibuprofen should be used with caution in those with a history of heart problems or high blood pressure.

Ibuprofen is not recommended during pregnancy or in nursing mothers.

Drug Interactions:

Ibuprofen can increase the effect of anti-coagulants.

Ibuprofen should not be taken with any other NSAIDs.

Because of the potent nature of this medicine, be sure to tell your doctor about any other medicines you are taking, including nonprescription medicines and vitamins.

Possible side effects:

These side effects are not considered serious but are certainly annoying for those experiencing them. The most frequently reported side effects include diarrhea or constipation, dizziness, drowsiness, gas, headache and nausea.

More serious side effects that you should report right away include blood in urine, black, tarry stools, chest pain or irregular heartbeat, difficulty breathing, skin rash, redness, blistering, peeling or itching, stomach pain or cramps, unusual bleeding or bruising, red spots on the skin, unusual tiredness or weakness, yellowing of the eyes or skin, ringing in the ears, swollen ankles or feet, vomit that looks like coffee grounds and any other unusual gastrointestinal symptoms.

Signs of a possible allergic reaction are rash, swelling and difficulty breathing. These symptoms should be reported immediately.

Precautions & Special Notes:

You will be required to have frequent blood work while on this medication. It is very important that you keep all lab and doctor?s appointments.

If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor at once. You may have a bleeding ulcer.?

For more information:

RxList Ibuprofen
MedicineNet Ibuprofen
Pharm Info Net Ibuprofen

References:
Mosby’s GenRx?, 10th ed. Copyright ? 2000 Mosby, Inc.
Complete Guide to Prescription and Nonprescription Drugs, H. Winter Griffith, M.D. , Copyright 1997
RxList.com