Indomethacin (Indocin)


What is Indocin? 

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID). It is indicated for the treatment of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, bursitis and/or tendinitis, and gout.

FDA approved:

June 1965

Average annual cost:

$21.82 25 mg 2 per day

Brand Names and International Availability:

Ainscrid 75mg LP (France); Amuno (Germany); Amuno Retard (Germany); Antalgin; Antalgin Dialicels (Mexico); Apo-Indomethacin (Canada); Areumatin (Indonesia); Argilex (Argentina); Artherexin; Arthrexin (Australia, South-Africa); Articulen (South-Africa); Artrinovo (Spain); Asimet (Malaysia); Bavilon; Benocid (Indonesia); Betacin (South-Africa); Bonidon (Costa-Rica, Dominican-Republic, Ecuador, El-Salvador, Guatemala, Nicaragua, Panama); Boutycin; Chrono-Indocid (France); Confortid (Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, Denmark, Finland, Norway, Sweden, Switzerland, Indonesia, Thailand); Confortid Retard (Denmark); Confortid Retardkapseln (Switzerland); Dolazal (Netherlands); Dometin (Netherlands); Durametacin (Germany); Elmetacin (New-Zealand, Germany); Flamaret (South-Africa); IDC (Thailand); Idicin (India); IM-75 (Argentina); Imbrilon (England, Ireland, Hong-Kong); Imet (Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe; Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, Italy); Inacid (Spain); Indacin (Japan); Indameth (US); Indecin; Indo (Malaysia); Indocap (India); Indocap S.R. (India); Indocen; Indocid (Australia, New-Zealand; Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, South-Africa, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe; Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, Taiwan, Thailand, Hong-Kong, Malaysia, Philippines, Canada, Mexico, Norway, Switzerland, Argentina, Belgium, Denmark, England, France, Portugal, Greece, Austria, Netherlands); Indocid PDA (Canada); Indocid R (Hong-Kong); Indocid-R (New-Zealand); Indocin (US); Indogesic (Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates); Indolag (Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe; Bahamas, Barbados, Belize, Bermuda, Curacao, Guyana, Jamaica, Netherland-Antilles, Surinam, Trinidad; Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates); Indolar; Indolar SR (England); Indomed (Australia, South-Africa, Israel); Indomee (Sweden); Indomelan (Austria); Indomet (Peru); Indometacinum; Indomethegan (US); Indometicina; Indometicina Gen-Far (Colombia); Indometicina McKesson (Costa-Rica, Dominican-Republic, El-Salvador, Guatemala, Nicaragua, Panama, Honduras); Indometin (Finland); Indomin (Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates); Indo-Phlogont (Germany); Indorem (Bahamas, Barbados, Belize, Bermuda, Curacao, Guyana, Jamaica, Netherland-Antilles, Surinam, Trinidad); Indo-Spray (Australia); Indo-Tablinen (Germany); Indotard (Israel); Indovis (Israel); Indox; Indoy (Taiwan); Indozu; Indrenin (Czech-Republic); Indylon (Bahamas, Barbados, Belize, Bermuda, Curacao, Guyana, Jamaica, Netherland-Antilles, Surinam, Trinidad; Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe); Inflazon (Japan); Inpan; Lauzit (Japan); Liometacen; Malival (Mexico); Malival AP (Mexico); Metacen (Italy); Methacin (Malaysia); Methocaps (South-Africa); Metindol (Thailand); Metocid; Mezolin; Mobilan; Novomethacin (Canada); Peralgon; Reflox; Reumacid (Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates); Reusin (Spain); Rheumacid (Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe); Rheumacin (New-Zealand); Rheumacin SR (New-Zealand); Salinac (Japan); Servimeta (Thailand); Servindomet (Thailand); Toshisan; Vonum (Germany)

How does it work?

Indomethacin has anti-inflammatory, antipyretic (fever reducing) and analgesic (pain relieving) properties. Its mode of action, like that of other anti-inflammatory drugs, is not known.

Dosage:

The recommended dose of Indomethacin is 25 mg two or three times a day. Maximum dose should be no more than 150-200mg per day.

How should I take it?

Indomethacin should be taken with food and a full glass of water.

Contraindications:

Those who have had a prior allergic reaction to other NSAIDs should not take indomethacin.

Indomethacin should be avoided in those with a history of peptic ulcer or GI bleeding. 

Indomethacin should be used with caution in those with a history of kidney problems.

Indomethacin may increase depression, epilepsy, and parkinsonism, and should be used with considerable caution in patients with these conditions.

Indomethacin should be avoided during pregnancy or in nursing mothers.

Indomethacin should be used with caution in those with a history hypertension or heart failure.

Drug Interactions:

Indomethacin can increase the effect of anti-coagulants.

Indomethacin should not be taken with any other NSAIDs.

Indomethacin may increase the effect of digoxin.

Because of the potent nature of this medicine, be sure to tell your doctor about any other medicines you are taking, including nonprescription medicines and vitamins.

Possible side effects:

These side effects are not considered serious but are certainly annoying for those experiencing them. The most frequently reported side effects include diarrhea or constipation, dizziness, drowsiness, gas, headache and nausea.

More serious side effects that you should report right away include blood in urine, black, tarry stools, chest pain or irregular heartbeat, difficulty breathing, skin rash, redness, blistering, peeling or itching, stomach pain or cramps, unusual bleeding or bruising, red spots on the skin, unusual tiredness or weakness, yellowing of the eyes or skin, ringing in the ears, swollen ankles or feet, vomit that looks like coffee grounds and any other unusual gastrointestinal symptoms.

Signs of a possible allergic reaction are rash, swelling and difficulty breathing. These symptoms should be reported immediately. 

Corneal deposits and retinal disturbances have been observed in some patients who had received prolonged therapy with indomethacin.

Precautions & Special Notes:

You will be required to have frequent blood work while on this medication. It is very important that you keep all lab and doctor’s appointments.

If you get black, tarry stools or vomit up what looks like coffee grounds, call your doctor at once. You may have a bleeding ulcer.

For more information:

RxList Indomethacin 
MedicineNet Indomethacin
 
Pharm Info Net Indomethacin

References:
Mosby’s GenRx®, 10th ed. Copyright © 2000 Mosby, Inc.
Complete Guide to Prescription and Nonprescription Drugs, H. Winter Griffith, M.D. , Copyright © 1997
RxList.com