What is it?
Sulfasalazine is a
Disease Modifying Anti Rheumatic Drug (DMARD). Originally used as a
treatment for ulcerative colitis and other inflammatory bowel
conditions. It was noted to
have the same inflammation reducing effect on inflammatory arthritis.
$186.15 - 500mg 4 per
Brand Names and
Colo-Pleon; Salazopyrin; Salisulf; Saridine; Sulfazine; Ulcol
How does it work?
It is not known
exactly how sulfasalazine works in inflammatory arthritis. It appears to
have a strong anti-inflammatory effect and also has immune suppressant
normally comes in 500mg tablets. Average maintenance dose is 2g (4
tablets) daily, although higher doses are not uncommon.
How should I take
Take sulfasalazine as
ordered, usually with a full glass of water. If stomach upset occurs,
take after meals.
Do not take if you
have a known sulfa drug allergy.
be avoided in pregnant and nursing mothers.
not be used in children under the age of two.
decrease the absorption of digoxin.
Because of the potent
nature of this medicine, be sure to tell your doctor about any other
medicines you are taking, including nonprescription medicines and
These side effects
are not considered serious but are certainly annoying for those
experiencing them. The most frequently reported side effects include
fatigue, nausea, headache, dizziness, diarrhea, increased sensitivity to
the sun, loss of appetite and orange/yellow skin or urine.
More serious side
effects that you should report right away include itchy rash, sore
throat, fever, blisters, reduced urine output, stomach cramps, unusual
bleeding or bruising, bloody stools.
Sulfasalazine has the
potential to cause kidney and liver problems and severe anemia.
Signs of a possible
allergic reaction are rash, swelling and difficulty breathing. These
symptoms should be reported immediately.
Due to the potential
for sun sensitivity exposure to direct sunlight should be avoided. If
you are in the sun please wear protective clothing and strong sun block.
You will be required
to have frequent blood work while on this medication. It is very
important that you keep all lab and doctors appointments.
cause a decrease in male sperm count. This is usually reversible once
the drug is discontinued.
Info Net Sulfasalzine
Mosby's GenRx®, 10</span><sup><span style="mso-bidi-font-size:7.5pt">th
ed. Copyright © 2000 Mosby, Inc.
Complete Guide to Prescription and Nonprescription Drugs, H.
Winter Griffith, M.D. , Copyright