Hylan G-F 20 (Synvisc)

What is it?

Hylan G-F 20 is a fluid containing hylan polymers produced from chicken combs.

FDA approved:

August 1997

Brand Names and International Availability:

Synvisc (US) (Canada)

How does it work?

The exact mechanism is unknown, however it is speculated that the quality and quantity of hyaluronate in the joint fluid and tissues may be deficient in those with OA. Adding Hylan G-f 20 allows the joint to function better.



Hylan G-f 20 is supplied in ml pre-filled syringes. It is administered by intra-articular injection once a week (1 week apart), for a total of 3 injections.�

How should I take it?

Your doctor will inject your knee once a week for 3 weeks.


Those allergic to products from birds such as feathers, eggs, and poultry should avoid this product.

The safety and effectiveness of Hylan G-f 20 has not been studied in children.�

Sodium Hylan G-f 20 should be avoided by those with known hypersensitivity to hyaluronate preparations.

Intra-articular injections are contraindicated in cases of infections or skin diseases in the area of the injection site.

The safety and effectiveness of the use of Sodium Hylan G-f 20
in joints other than the knee have not been established.

The safety and effectiveness of sodium
Sodium Hylan G-f 20
have not been established in pregnant or nursing women.

Should be used with caution when there is evidence of lymphatic or venous stasis in that leg.

Drugs Interactions:

Should not be used with disinfectants containing quatemary ammonium salts for skin preparation because hyaluronic acid can precipitate in their presence.

Do not inject anesthetics or other medications into the knee joint during Synvisc therapy. Such medications may dilute Synvisc and affect its safety and effectiveness.

Possible side effects:

These side effects are not considered serious but are certainly annoying for those experiencing them. The most frequently reported side effects include gastrointestinal complaints, headache, injection site pain, knee swelling/effusion, and rash, bruising, and itching at the injection site.

Signs of infection at the injection site include fever, redness, swelling and pain. If you suspect an infection notify your doctor right away.

Signs of a possible allergic reaction are rash, swelling and difficulty breathing. These symptoms should be reported immediately.�

For more information:

Mosby’s GenRx�, 10th ed. Copyright � 2000 Mosby, Inc.