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when your Methotrexate is due by your pain?  It seems weird, but I take mine on Thursday's, and Wednesday nights - Friday are my worst days.  Is it my imagination?  It makes me feel like a "crack whore" sometimes, like I need my next "fix".

Sorry, you feel that way. Just wait until you get on biologicals.

Oh and my hubby... he says he feels like a drug dealer, because he has to open all my pill bottles for me and give me my meds and sometimes I hound him for a while before he decides to give them to me. Like when he is watching tv he does not want to get my meds until it goes to commercial or the movie is over with.

I can definitly tell when Im ready for my next dose of Mtx.  Im the same way when it is time for my Humira also. I can tell if I miss it.. the next day I'm saying  oh crap I forgot..  believe me I notice.Yep... when I was on Humira... I use to ask hubby if it was time yet, and it would be like 2 days before I was to get it again. He use to talk about how if someone over heard our conversation they would think I was a junkie needing a fix  Yea Im ususally the worst the day after I take my shots I used to have that experience but not anymore. Mine is due in a few hours
and I feel the same as I did 3 days ago. Yeah I have the same experience.  I take both my enbrel and my MTX (injectible) on thursdays, and I can feel that its wearing off leading up to Thurs night.  Fridays I'm really achy.  If I move it back a day, I get really bad leading up to it, and the day after I take it.  Nope, not your imagination!  Unless we're all imagining it together . Yes. I can definately tell.Thanks for the responses.  Gimpy why do you think you're not effected the same way anymore?  What made it change?

Sometimes I notice and sometimes I don't. I take the MTX on Weds and Enbrel on Sat. Maybe that has something to do with it?

Hope everyone's having a superfantastic and comfortable evening!
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