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Whats the shortest duration it took mtx to start working? i am currently in enbrel,it just wasnt doing the job,so they put me on mtx.4ml needle so i am wondering if i am truly going to have to wait 4 months for the med to beging to help

kel

Hi Kel,

I can't imagine mtx taking that long. I hear you say you are on injections? I am on the tablets and they worked in a few weeks. I don't know what the official time is I'm sorry but for me personally it didn't take that long. It sounds as though you have to be very carefuly with infections. I have never had problems with bad infections on mtx and have been on and off it for 14 years now. Maybe I am one of the lucky ones. I just make sure that I don't go in the sun which is a major thing to worry about. On the day I take mtx I plan a very quiet day so that if I feel off then I can just relax. It usually works for me. Have they put you on folic acid as well?

Sorry I couldn't be more help but good luck with the mtx. Take care

Howdy Kel!
I'm on injectable MTX too!  I take 25 mg a week (woohoo), and am on enbrel as well.  And no, if you have to wait four months to feel effects, then its not working.  My rheumatologist told me that the MTX would help as much as it could in 6 weeks.  I've noticed improvement in 3-4.

So far, there hasn't been enough of effect at 6 weeks, and they bump me up.  I'm now at the max dose, so hopefully this one will work.  If not, then we get "creative"--the nurse practitioner's words, not mine kschultea39455.2809722222My RD is wanting me to switch from sulfasalazine to mtx.  I am very worried about nasty side effects.  Are they usually really bad or are they just "covering our butts warnings"?  My next rd appt. is in feb and I have to decide by then.  I am in pain all the time and having to take pain pills more often than I would like to so I am coming to the conclusion that I need stronger meds but it is very scarey.....As far as side effects go, I had fairly significant nausea, headaches and mood swings on the pill form.  I switched to the injection form...gosh...I guess its been about 3 months ago now...wow time goes fast.  The nausea and headache disappeared.  The mood swings had already diminished before I switched...still have mood swings sometimes, but I don't think I can blame that on the meds, only on me being a girl (silly periods!) thanks that does help the hair loss thing was probally scaring me the most.  I know that is very vain, but I have always had a fear of balding.  anyway my head is saying I need to switch but my gut is well churning.

Kel; I take the pills so I can't really understand what does you're at. It was my experience though that the lower dose wasn't effective for me.

Once I was increased to a higher dose I got extremely good results. I'd highly recommend this medication to anyone that can tolerate it.

I've been on MTX (20 mg. pills)  and Plaquenil since May of last year and it took a few months for me to feel better, although I think it's  going to have to be bumped up.  I also was terrified of starting it, but except for feeling really crummy at first, (when I took all the pills at once), it's been quite easy.  Splitting the dose helps cut down on the immediate side effects, if you have any at all. And of course, you need the folic acid too.  I just recently started thinking my hair may be a bit thinner, but it could be my imagination.  It's slight, if at all. All it all, it's not nearly as bad as I feared and yes, some of those warnings are "covering their butt" because even if one person out of thousands in the trials had a side effect, they have to list it, according to my RD.  I truly understand your reluctance, but I think it's worth giving it a shot.  It's a miracle drug for many.  Lol that sounds like me as well.  I knew I probably should go ahead and start it, but I was stubborn and told my doctor no for three months.  At the end of that, when I was still having more bad days than were necessary, I came to the realization that I was a 22 year old Spanish major telling a rheumatologist who spent who knows how many years in school and residency pursuing his speciality "no".  I felt silly and started the MTX.
I came to the forum too and asked about side effects, and several folks told me that they did suffer hair loss, and other side effects.  I haven't tho.  I think its highly dependent upon the individual.  I was also told that, if hairloss starts, going off the MTX will let it start growing back.  Oh, and I take my folic acid everyday...its supposed to help with the side effects, including the potential hair loss. 
Anyway, like I said, I held out starting for a while.  It did help a lot tho
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