It's been a tough time waiting for some type of balance in the RA treatments. I am seronegative and have been on treatment for almost a year. I will see my rheumatologist again in two weeks. I always feel un-well,for days, after taking 10 mg MTX on Fridays. I was also taking SFZ but I had a few weeks when I had continuous "flushed face". I have ordered the book on TNF Miracle blockers. I am trying to get some insight into what might eventually work. I used to be so active, doing aerobics 4 times a week for an hour ; I was consided a "gym rat" ! Again, perhaps in time. It is encouraging to read all of your stories and advice.. Hope is a bright beacon, sometimes near, sometimes far, but always there. Hi there, welcome to AI.Do you take anything with your MTX. Yes there is always hope and while theres hope there is life. Its hard having to give up activites but instead of giving up on them maybe scale them down and do other forms of exercise like swimming, yoga or tai chi. It depends on your limits. I hope your rheumys appointment goes well.