Female:Male Ratios in Autoimmune Ilnesses | Arthritis Information

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Table I
Female:Male Ratios
in Autoimmune Diseases

Hashimoto's disease/hypothyroiditis 50:1

Systemic lupus erythematosus 9:1

Sjogren's syndrome 9:1

Antiphospholipid syndrome 9:1

Primary biliary cirrhosis 9:1

Mixed connective tissue disease 8:1

Chronic active hepatitis 8:1

Graves' disease/hyperthyroiditis 7:1

Rheumatoid arthritis 4:1

Scleroderma 3:1

Myasthenia gravis 2:1

Multiple sclerosis 2:1

Chronic idiopathic thrombo-
cytopenic purpura 2:1


http://www.aarda.org/women.php

Why more women than men?  Why do the ratios equalize in most cases post menapause?
 
These numbers are why I believe there must be some sort of hormonal connection to this whole thing.  These ratios are the main reason I have any issues with the infection conneciton as a sole source of these diseases.  Infections have never shown a propensity towards one sex or another...they are equal opportunity invaders.  I'm not discounting infection theory...I just believe there is a piece still missing and hormones may be the answer. 
I'm with ya, Buckeye.  Hormones must have an impact --  highlighted in that women go into remission during pregnancy.  Again, it doesn't discount other contributing factors, just strongly suggests that one piece of the pie includes hormones.
Buckeye -
 
You have to check out the HPA Axis - seriously, I've got (somewhere) research showing myco's love hormones.  They amp the infection rate in the Axis.  Thyroid.  Adrenal.  Insulin.  Melatonin.  Did you know melatonin is a neurohormone?  No wonder we don't sleep.  I'll try to look for it tomorrow for you. 
 
There's the hormone connection to infection!  It's why we get hit harder then men.
 
Pip
Because I like to throw kinks into things................................



How much of the ratios are skewed because men tend NOT to visit their docs? How many men have some of these diseases and never get DXed? Think about it.
Katie
I really don't think men not going to the doctor would scew the numbers that far.  Even men will go to the doctor with the symptoms that come along with the listed diseases.  it may take them more time before they give in but they go.  
 
Pip
I'd love to see the studies.
buckeye2008-03-21 04:32:41Gee what a Lucky guy I am. I bucked the odds !!!Like all studies, you have to look at the pop being studied. without looking at the study, not sure what ages they were studying, or if it was just a compilation of Dr. stats of their patients ect.Dunno though interesting.
 
Also, does it account for JRA......if hormonal, how does JRA fit in? Obviously something is awry with the hormonal, cell structure, perhps even an infection induced??????
 
Just questions, not criticism......more curiousity than anything.
Jra is more common in girls too. Don't know how much though. But I would think the numbers would not be as messed up by men not going to the doc in JRA because Mommy makes you go to the doc! Very interesting. 

IDK what this has to do with it, but it's bothered me since re-diagnosis last year.  I was 10 y/o when I was DX's w/ JRA.  At age 12 had surgery for a knee cap that deteriorated .. then puberty and very little flaring or any symptoms for the most part for 30 years!!  THEN, into menopause, I began again with flares and swelling and major pain and all kinds of additional symptoms related to RA ..  doesn't make much sense, or does it?
babs102008-03-21 06:12:31

It does. I wish my JRA would go away! I had a 6mos break when I was 16 and then it came back as a horrible monster! I am flaring bad right now for the past month. OY! Last night I broke down bawling because I am so fed up with the flare. My poor hubby! I feel so bad for him, I have been an emotional roller coaster for a couple days now...maybe more...and I can't do anything for him because I hurt so bad, not even clean or cook, or anything!

Jode
even children have hormones.  My personal pet theory it that things happen in our development in utero which messes up our immune systems.  It may be something as simple as a day either direction in the develpment timeline when a hormone or other chemical is supposed to turn on or off which then effects how a cell develops. 
I think the skewing of numbers for RA is pretty easy to see. First off RA is hard to diagnose properly and rigorous in its terms so many cases never hit the charts, secondly women seem to get it early on so statistically they're building numbers over a longer period of time. Third, men who might have RA or will have it die from other causes because they won't get symptomatic until past 50 years of age.

mab522008-03-21 09:31:46Mab....RA is no more difficult to diagnose than the other diseases listed.  In fact some of those might be more difficult.  And men don't die that much earlier that across a population it would scew the stats that far. 
 
Supposedely women get RA far more often pre menapause...post menapause the numbers are equal
[QUOTE=buckeye]Mab....RA is no more difficult to diagnose than the other diseases listed.  In fact some of those might be more difficult.  And men don't die that much earlier that across a population it would scew the stats that far.  in my family, i have RA, grandma (mom's mom) has crohn's, dad has RA and his brother has crohn's.  Kind of 50/50 in my family. [QUOTE=bubbagump]in my family, i have RA, grandma (mom's mom) has crohn's, dad has RA and his brother has crohn's.  Kind of 50/50 in my family.[/QUOTE]

Misery equally divided Interesting topic!  I never had a single joint issue until about 1 year after my complete hysterectomy.  My ovaries were removed so I avoided instant menopause by beginning HRT, which I gave up on after a year, fearing they were more dangerous to my health than
menopause was.  It was shortly after stopping hormone replacement that I developed symptoms of RA.
 
I'm thinking that hormones may indeed play a huge role in the onset of this disease!
WOW! I have JRA though, thats a different monster. Hormones may be involved just I would imagine in a different way.
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