I think I've read that some people take their mtx the same day as their biologic, because it helps the biologic work better. Is this recommended by your doctor or is it your own observation? Would that be harder on your liver, or is it better to do all the toxins at once?I take mine on the same day. I do it just so I only have to think about taking medicine one day a week. My RD knows I take them both together and has never said anything for or against it.i did it simply to remember to take them both..nothing scientific about itI always preferred just getting it over with all at one time. Like Linn said; you only have to think about it that one day.