I only took 4 doses: Thurs PM, Fri AM/PM and Sat AM before stopping because I thought I was having an allergic reaction: intense itching in my joints of fingers and toes. It's been 48 hours since my last dose and I'm still having small bouts of itching. Do you think its still the Celebrex working its way out or can RA present itself as itching and it wasn't the meds at all? It seems a bit odd that the meds would cause itching in JUST my fingers and toes but anything is possible! Just trying to make sense of it before I call my dr and they think I'm nuts!I have no idea. However, my RD did tell me that NSAIDs (generally) can take up to 5 days to be effective. Which would make me think that they stay in your system at least that long? But I'm just guessing. Hope you get some relief soon!