pip yoohooo | Arthritis Information
hi pip i see you mention vit d sensative
what effects would a person see if they were sensative..
allso is it possible to take to much calcium..
Boney
Hey boney... do not know if this will help, but this is what is on the calcium & vitamin D sheet my RD gave me.
Although calcium and vitamin D will not build bone. both will strengthen exisiting bone. Many foods can be eaten to insure adequate calcium intake. However, many Alabamians also need a calcium supplement to ensure their recommended daily allowance. For most Floridians who get out in the sun at least 30 mins over a week's time frams, vitamin D supplementation may not be needed.
If taking calcium supplements, it is of utmost importance to monitor your element calcium intake, this is the amount you are actually abosrbing. However, many people will need some sort of supplement with their dietary measures to ensure efficient absorption.
Be careful not to intake xcessive amounts of vitamin D that could have devastating side effects. The recommended daily intake is 400 IUs.
A few other helpful hints geared to help protect your bones strength is to stay away from activities which diminish your absorption of calcium. Too much of the following can actually strip the calcium out of your bones and induce bone loss prematurely:
- Heavy caffeine intake (soft drinks, coffee)
- Heavy alcohol consumption
- Too much refined sugar in diet
- Inactivity / confinement
- Space travel due to lack of gravity
Yeah... that last one is a little odd to me. But I guess that is incase you decide to board a space shuttle and go to the moon. LOL!
Oh and there is even a phone number you can call!
Calcium Information Center at 1-800-321-2681
Hey Boney -
That's part of my problem, I keep finding references to Vitamin D sensitivity but no real science. You guys think it's just Pharma I distrust - but it's not - it's anybody with something to sell instead of 'helping' us.
Most of the studies that have come out on D recently were bought and paid for by the Vitamin D Council. They're pretty much the same as Pharma - publishing questionable research in order to push their products. Almost every 'respected' scientist involved in the studies have been busted for 'conflict of interest'. In fact, I don't think Nikkilynn had one left that wasn't bought and sold.
The Vitamin D council mentions 'hyper D sensitivity' as being rare - but some of the things I found described it as sounding pretty much like all of us with AI diseases.
This is a pro-D study that does say the problem is in the ratios - but even tho some people have this problem - we should still raise the MDR levels. He goes about dissing all the scientists that are saying there is toxicity - but I haven't pulled the original studies to figure out how that effects us.
Here's an press release coming from the 'no D' circle. One part of the article that got my attention - even with the increase in supplementation, disease rates continue to rise.
This is a portion of a post I made on AF -
Now this is cool! Discussion!
OK, what I'm getting is only raising more questions.
Apparently, from Grandpavan's research, Marshall is right. Vitamin D IS a powerful steroid hormone. Even the Vitamin D Council is saying that. However, we must question the impartiality of the Vitamin D counsil. Sigh.
Which brings us to the hormone question again.
And...is this good for us? Of course we feel better on it...it's a steroid. But as we know, too much Pred is NOT good for us.
I found this on their web page. This is a treatise telling us too much D fears are unwarrented. Most of what he says makes sense...however there are two paragraphs that bears scrutiny.
It is true that a few people may have problems with high calcium due to undiagnosed vitamin D hypersensitivity syndromes such as primary hyperparathyroidism, granulomatous disease or occult cancers but a blood calcium level, PTH, 25(OH)D, and calcitriol level should help clarify the cause of the hypersensitivity. Although D can be toxic in excess, the same can be said for water.
Correct me if I'm wrong, but aren't those diseases things a lot of us have?
It goes on to say -
Hypersensitivity, Not Toxicity.
Vitamin D hypersensitivity syndromes are often mistaken for vitamin D toxicity. The most common is primary hyperparathyroidism. Other syndromes occur when abnormal tissue subverts the kidney's normal regulation of endocrine calcitriol production. Aberrant tissues, usually granulomatous, convert 25(OH)D into calcitriol causing high blood calcium. The most common such condition is sarcoidosis, oat cell carcinoma of the lung and non-Hodgkin's lymphoma but other illness can cause the syndrome and they can occur while the patient's 25(OH)D levels are normal or even low. For that reason, while rare, it is advisable to seek a knowledgeable physician's care when repleting your vitamin D system, especially if you are older, have sarcoidosis, cancer or other granulomatous diseases. In such high-risk patients, periodic monitoring of 25(OH)D levels and serum calcium will alert the physician to the need to do more tests, such as calcitriol or PTH, and take further action.
Again, I'm seeing a connection here - and probably why Marshall focused on this. He has Sarc.
It's looking to me, preliminarily, that D may indeed be bad for us and that quite a few of us should have further testing before self medicating with D.
Pip
P.S. Who knows anything about the 4 tests?
And a thyroid board talking about it -
A response I got to one of my posts -
Hey Pip...I would not be surprise about a correlation there. Did you have a look at the paper? I like the part he says that 1,25-D can also bind the clucocorticoid receptor!!! I do not know if there is enough scientific evidence for that, but is an interesting hypothesis to test.
I think is very interesting the point about antibacterial peptides expression regulated by VDR.
I am also thinking about Lupus patients being sensitive to sun exposure.
I have to admit that I never care about Vit D because I am lucky enough to live in a tropical country with LOTS of sun exposure...but this is all very interesting
Another persons reply -
The above link is really for MS but it has some interesting information. The last section in particular gives me a rough idea of how complicated the immune system is. Some RA medications target certain IL cytokines and the TNF so if D3 enhances those cytokines it may be bad for people with RA. I'm not sure I understand enough about it so I might have it backwards. Maybe this will make more sense to others. God bless.
And finally - CFS link to D receptors - possibly why more women get these diseases.
Pip
Hmmm......maybe I should rethink my upcomming voyage into space? Oh and Pip, I will happily vouch for your demented toe. Looking forward to when you get back to MI :)
Bioactive
vitamin D or calcitriol is a steroid hormone that has long been known
for its important role in regulating body levels of calcium and
phosphorus, and in mineralization of bone. More recently, it has become
clear that receptors for vitamin D are present in a wide variety of
cells, and that this hormone has biologic effects which extend far
beyond control of mineral metabolism.
Vitamin D is well known as a hormone involved in mineral metabolism
and bone growth. Its most dramatic effect is to facilitate intestinal
absorption of calcium, although it also stimulates absorption of
phosphate and magnesium ions. In the absence of vitamin D, dietary
calcium is not absorbed at all efficiently. Vitamin D stimulates the
expression of a number of proteins involved in transporting calcium
from the lumen of the intestine, across the epithelial cells and into
blood. The best-studied of these calcium transporters is
calbindin, an intracellular protein that ferries calcium across the intestinal epithelial cell.
Vitamin D receptors are present in most if not all
cells in the body. Experiments using have
demonstrated that vitamin D has potent effects on the growth and
differentiation of many types of cells. These findings suggest that
vitamin D has physiologic effects much broader that a role in mineral
homeostasis and bone function. This is an active area of research and a
much better understanding of this area will likely be available in the
near future.
The classical manifestations of vitamin
D deficiency is rickets, which is seen in children and results in bony
deformaties including bowed long bones. Deficiency in adults leads to
the disease osteomalacia. Both rickets and osteomalacia reflect
impaired mineralization of newly synthesized bone matrix, and usually
result from a combination of inadequate exposure to sunlight and
decreased dietary intake of vitamin D.
Excessive exposure to sunlight does not
lead to overproduction of vitamin D. Vitamin D toxicity is inevitably
the result of overdosing on vitamin D supplements. Don't do this!
Ingestion of milligram quantities of vitamin D over periods of weeks of
months can be severely toxic to humans and animals.
Joonie: If the combination of vitamin d and calcium didn't have any affect on bone strength, which is the result of enough calcium, doctors wouldn't be recommending people take them.
My worry is WHY aren't we metabolizing these minerals and hormones correctly? We're taking it in - why isn't it going where it's supposed to go? Notice - almost all AI people are low on calcium, magnesium and potassium. We are resistant to insulin, estrogen, D etc - all hormones.
We're being Hijacked!
Please look at the list above of some of the examples of 'hypersensitivity'. I know I've seen posts here of people with granulomas, thyroid disease, kidney disease etc.
Please, I'm begging here - get that Vitamin D3 test! Get them all. The DANGER is when you convert the D wrong. That's when it becomes toxic.
Hugs
Pip
P.S. Linda, was supposed to be there this month but messed up getting the tickets (NOT my fault). Maybe over the summer!
woah a lot to read here. think i will have to read twice..
This is interesting to me because at my last RD appt. she told me my bloodwork showed my parathyroid hormone (which regulates calcium) and my serum calcium were both slightly high...apparently this is odd because when one is high the other is supposed to be low. So the next step was to test my Vitamin D level, which I haven't done yet. ok thanks for the info joonie.. about spacetravel
if you have the odd million dollars to spare. you can book a flight into space...true...
spacedout Boney..
pip i have seen magnesium and potasium on my blood tests but not
vit d or calcium... this is all very interesting. i must ask about the tests..
never realised there was so much to it..
Boney
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