This is about diabetes, but I think it could apply to other chronic conditions:
http://blogs.wsj.com/health/2008/06/06/medicine-by-the-numbers-isnt-enough/
From the article:
"Krumholz cites other recent studies that showed that a strategy that
should theoretically improve outcomes made no difference or made things
worse."
The link didn't work for me until I removed the 20% it tacked on the end.
one thing missing in the biomarker related research is they forget to integrate the individual signalling pathway/molecule into the whole physiology system, that’s why nothing works. medicine is not just about DNA, it is about the physiology homeostasis, DNA/gene is just a tool.