TV program said no to probiotics | Arthritis Information

I was watching a health program on tv last week and they stated that taking probiotics etc. can make your disease worse.

They stated that many items like probiotics help build up your immune system making it stronger, and when it is stronger, you get worse.

Things like omega 3 are ok as they work differently, they work directly to take away inflammation and don't work directly to build the immune system.

After watching it, it made so much sense.

I am going to try and find articles that might say the same. I stoped taking my probiotics and actually have been feeling a bit better. Not sure yet if it was it or not.

I wish i knew what the show was, it was on a small tv at wow wingery restaurant lol.

Oh boy, I'm getting confused. I know that it's not good to do anything to boost our immune system, but I thought probiotics was just trying to "level the playing field" and balance the flora. How can that be bad? Here is some food for thought -

1: J Neuroimmune Pharmacol. 2007 Dec;2(4):329-37. Epub 2007 Sep 8. Links
Evidence for neuromodulation of enteropathogen invasion in the intestinal mucosa.Schreiber KL, Price LD, Brown DR.
Graduate Program in Neuroscience, University of Minnesota, 1988 Fitch Avenue, St. Paul, MN 55108-6010, USA.

The extensively innervated intestinal mucosa encompasses a vast surface exposed to an array of potentially infectious microorganisms. We investigated the role of enteric nerves in modulating intracellular internalization of a multidrug-resistant Salmonella typhimurium DT104 field isolate in mucosa-submucosa sheets from the porcine ileum, a biomedical model for the human intestine. The effects of transmural electrical stimulation and drugs on intracellular internalization of Salmonella over 90 min was determined by a gentamicin-resistance assay relative to untreated tissues from the same animal serving as controls. The actin inhibitor cytochalasin D reduced internalization of Salmonella, and the mucus-disrupting agent dithiothreitol decreased its mucosal adherence. Transmural electrical stimulation increased, and neuronal conduction blockers saxitoxin and lidocaine decreased Salmonella internalization in stimulated and unstimulated tissues. Furthermore, the alpha-adrenergic/imidazoline receptor ligand phentolamine and the 5-HT(3) receptor antagonist tropisetron decreased internalization in stimulated tissues. Based on these findings, enteric neural activity appears to modulate interactions between the intestinal mucosa and pathogenic bacteria.

PMID: 18040851 [PubMed - indexed for MEDLINE]

These look AI to me -

http://www.journals.uchicago.edu/doi/abs/10.1086/523333

SUPPLEMENT ARTICLE
Clinical Indications for Probiotics: An Overview
B. R. Goldin and
S. L. Gorbach

Tufts University School of Medicine, Boston, Massachusetts

Reprints or correspondence: Dr. Barry R. Goldin, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111 (barry.goldin@tufts.edu).

Probiotic bacteria are used to treat or prevent a broad range of human diseases, conditions, and syndromes. In addition, there are areas of medical use that have been proposed for future probiotic applications. Randomized double-blind studies have provided evidence of probiotic effectiveness for the treatment and prevention of acute diarrhea and antibiotic-induced diarrhea, as well as for the prevention of cow milk–induced food allergy in infants and young children. Research studies have also provided evidence of effectiveness for the prevention of traveler’s diarrhea, relapsing Clostridium difficile–induced colitis, and urinary tract infections. There are also studies indicating that probiotics may be useful for prevention of respiratory infections in children, dental caries, irritable bowel syndrome, and inflammatory bowel disease. Areas of future interest for the application of probiotics include colon and bladder cancers, diabetes, and rheumatoid arthritis. The probiotics with the greatest number of proven benefits are Lactobacillus rhamnosus strain GG and Saccharomyces boulardii.

How it works to cut inflammation - with arthritis!

Mol Immunol. 2008 Feb 1; : 18243320

Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions.

[My paper] Jae-Seon So , Ho-Keun Kwon , Choong-Gu Lee , Hwa-Jung Yi , Jin-A Park , So-Yeon Lim , Ki-Chul Hwang , Young Ho Jeon , Sin-Hyeog Im

Although the beneficial effects of probiotics on wide variety of diseases have been shown, little is known about how probiotics modulate the immune system. In this study we elucidated the underlying mechanisms how Lactobacillus casei (L. casei) protects against rheumatoid arthritis (RA) progression by investigating the effector functions of CD4(+) T cells. Oral administration of L. casei suppressed collagen-induced arthritis (CIA) and reduced paw swelling, lymphocyte infiltration and destruction of cartilage tissue. L. casei administration reduced type II collagen (CII)-reactive proinflammatory molecules (IL-1beta, IL-2, IL-6, IL-12, IL-17, IFN-gamma, TNF-alpha and Cox-2) by CD4(+) T cells. L. casei administration also reduced translocation of NF-kappaB into nucleus and CII-reactive Th1-type IgG isotypes IgG2a and IgG2b, while up-regulating immunoregulatory IL-10 levels. Our results suggest that oral administration of L. casei suppresses the type II collagen-reactive effector function of Th1-type cellular and humoral immune responses in arthritic inflammation.

Also, if you want real science, instead of some TV report - Google PubMed and search for probiotics.

Bubba - when did you stop the probiotics? Before or after you realized about the gluten?

Pip

I heard a radio report that if someone is seriously ill, probiotics will hurt them. I always wonder who is funding these studies. That should be included to know why they are done.

Jan

No one should run out and change their treatment plans based on a TV or radio show. Talk it over with your doctor, your pharmacist, and do research on your own. the report the Jan heard was specifically in reference to serious liver, pancreas disease. Probiotics should be avoided in these cases.

Bubba..as many issues as you have you really should be running everything by your own doctors. If you felt worse on probiotics then stopping them was probably the correct decision even if others may disagree. You know your body we don't. You might though, with your lactose and glucose issues double check the inactive ingrediants in the probiotic pills you were taking. Its possible that they contained one of those products

[QUOTE=buckeye]the report the Jan heard was specifically in reference to serious liver, pancreas disease. Probiotics should be avoided in these cases.

[/QUOTE]

And if one has serious issues like that, even more reason to discuss with your medical team before changing anything. There could still be compelling reasons why a doctor might want someone to use probiotics, despite such diseases; it's probably not a wise choice to just stop treatment without discussing the pro's and con's with the doc first. That's all.I agree that many of these TV programs are actually paid advertisement and definately biased. Always discuss anything with your physician.Probiotics are extremely safe...and necessary when you are taking meds that can destroy your normal flora such as antibiotics. I would not listen to a commercial. Buckeye -

On PubMed there are a ton of liver and pancreas studies saying probiotics help. ESPECIALLY in liver disease. And I think pancreas too.

There's only one probiotic study that ended up 'adversely' and that's the Winslow one where they screwed up and did a feeding tube of probiotics directly into the duodendum. All we know (so far) is that whatever med they were studying was not antibiotics. All the European Union did is say 'no probiotics for people on feeding tubes' and not even taking into consideration that they ran it into the duodendum.

Hugs,

Pip