Long story short...he thinks I may have Reactive Arthritis. In any event he wants me to try Arava before biologics, said 2/3 of those who don't respond to mtx respond to arava. Will also stay on Plaquenil. He was excited about a new blood test that he is running on me. Not sure what but they set me up with an account where I can check my bloodtest results online and communicate with the office. Back in 2 months, really happy with visit.Arava is a good medicine. It made me feel great, i had an allergic reaction to it. The last time my swelling went away was after i took the Arava. Somedays i think i would like to take it again but i know i can not. Also it is a fast acting med. Compared to many others. If you remember find out what the new blood test is?Have you researched reactive arthritis? I wasn't familiar with it, but there is involvement of the urethra and skin lesions. I didn't remember you talking about those symptoms, but I'm not a big time poster.Will post about the bloodwork! I had a bout of what I thought was IC (bladder pain) right before huge flare. But I hadn't felt well before that. I am seronegative and inflammation is asymmetrical and in bigger joints so that is part of it I guess...I imagine blood test is some new antibody or marker test?I don't have any advice, I am just happy that you are getting somewhere!! Keep us posted!I'm gonna have to google it.