Something has happened to me that I havn't read before. I have been on pred. for 2 years w/a high dosage of 10 and the last three months of 1 1/4 mg. I went to the doc and complained bitterly about the weakness in my legs, awful fatigue then abdominal pain , pain in my upper arms, shoulders back of neck. He just said "you need to get off the pred.". Then I went to an endocronologist and she ran a couple of tests. She said my adrenal glands were not producing ANY cortisol and the test read "l" and normal is 6 to 20. So I have induced addisons disease. She immediately started me up on 5, just to get normal again but my adrenal glands may never start producing again. I think the docs who know we have been on pred a long time need to pay attention to testing to what our glands are really doing when we taper. This could land us in the hospital or worse.