Low vitamin D linked to Parkinson's | Arthritis Information

This should help Lynn492009-01-07 10:06:58Lynn. A question. Which is bettter. Daily dosing, or weekly high dosing? Have you read which is better?"A team of Emory University School of Medicine scientists compared 100 Parkinson’s patients to the same number each of Alzheimer’s sufferers and healthy control subjects in order to evaluate the possibility that neurodegenerative diseases in general lead to vitamin D insufficiency, says author Marian Evatt, assistant professor of neurology at Emory.

There are some doctors believe that people with disease have less Vitamin D because a lot of disease genes use D25 to express themselves, so the disease is using the Vitamin D to get stronger, and that's why patients have low vitamin D when tested.

So what came first? The deficiency or the disease?

I have no idea which side is correct. I just thought I'd throw that in there since there's no "Don't Supplement with Vitamin D" Lobby group.

From Wikipedia:
"Marshall concluded that ARBs produce unexpected symptoms in sarcoidosis patients by directly affecting the immune system. Later, in 2006, he performed a study using mathematical modeling and molecular genomics to examine how ARBs are able to modulate the nuclear receptors of the immune system. He concluded that these models show that the vitamin D receptor (VDR) must be activated in order for the body to mount a correct innate immunity response.[32]
He did further studies in molecular modeling in order to understand the precise effect of vitamin D metabolites on the VDR. He concluded that 25-hydroxy vitamin D, which has the actions of a steroid, binds and inactivates the receptor, shutting down the body’s first line of defense against intra-cellular infection.[33]
In 2008, Marshall published a paper exploring how, in his words, "lifelong supplementation of the food chain with vitamin D might well be contributing to the current epidemics of obesity and chronic disease."[34]"[QUOTE=Gimpy-a-gogo]"A team of Emory University School of Medicine scientists compared 100 Parkinson’s patients to the same number each of Alzheimer’s sufferers and healthy control subjects in order to evaluate the possibility that neurodegenerative diseases in general lead to vitamin D insufficiency, says author Marian Evatt, assistant professor of neurology at Emory.

There are some doctors believe that people with disease have less Vitamin D because a lot of disease genes use D25 to express themselves, so the disease is using the Vitamin D to get stronger, and that's why patients have low vitamin D when tested.

So what came first? The deficiency or the disease?

I have no idea which side is correct. I just thought I'd throw that in there since there's no "Don't Supplement with Vitamin D" Lobby group.

From Wikipedia:
"Marshall concluded that ARBs produce unexpected symptoms in sarcoidosis patients by directly affecting the immune system. Later, in 2006, he performed a study using mathematical modeling and molecular genomics to examine how ARBs are able to modulate the nuclear receptors of the immune system. He concluded that these models show that the vitamin D receptor (VDR) must be activated in order for the body to mount a correct innate immunity response.[32]
He did further studies in molecular modeling in order to understand the precise effect of vitamin D metabolites on the VDR. He concluded that 25-hydroxy vitamin D, which has the actions of a steroid, binds and inactivates the receptor, shutting down the body’s first line of defense against intra-cellular infection.[33]
In 2008, Marshall published a paper exploring how, in his words, "lifelong supplementation of the food chain with vitamin D might well be contributing to the current epidemics of obesity and chronic disease."[34]"[/QUOTE] No, Lynn, I am participating intelligently in this discussion about Vitamin D.

Does every thread have to degenerate into a fight with you?[QUOTE=lorster]Lynn. A question. Which is bettter. Daily dosing, or weekly high dosing? Have you read which is better?[/QUOTE] whoa!  that's alot of information!!  [QUOTE=Gimpy-a-gogo] "A team of Emory University School of Medicine scientists compared 100 Parkinson’s patients to the same number each of Alzheimer’s sufferers and healthy control subjects in order to evaluate the possibility that neurodegenerative diseases in general lead to vitamin D insufficiency, says author Marian Evatt, assistant professor of neurology at Emory.

There are some doctors believe that people with disease have less Vitamin D because a lot of disease genes use D25 to express themselves, so the disease is using the Vitamin D to get stronger, and that's why patients have low vitamin D when tested.

So what came first? The deficiency or the disease?

I have no idea which side is correct. I just thought I'd throw that in there since there's no "Don't Supplement with Vitamin D" Lobby group.

From Wikipedia:




"Marshall concluded that ARBs produce unexpected symptoms in sarcoidosis patients by directly affecting the immune system. Later, in 2006, he performed a study using mathematical modeling and molecular genomics to examine how ARBs are able to modulate the nuclear receptors of the immune system. He concluded that these models show that the vitamin D receptor (VDR) must be activated in order for the body to mount a correct innate immunity response.[32]
He did further studies in molecular modeling in order to understand the precise effect of vitamin D metabolites on the VDR. He concluded that 25-hydroxy vitamin D, which has the actions of a steroid, binds and inactivates the receptor, shutting down the body’s first line of defense against intra-cellular infection.[33]
In 2008, Marshall published a paper exploring how, in his words, "lifelong supplementation of the food chain with vitamin D might well be contributing to the current epidemics of obesity and chronic disease."[34]"[/QUOTE]



well sheesh, now i have to ask, should i take it or not?
lorster2009-01-07 17:19:15Lorster, also some doctors believe that if you take oral vitamin D supplements it eventually interferes with or creates and inability for your body to synthesise vitamin D itself, so if you do decide to "supplement" vitamin D the tanning bed is the way to go.And I'm always lecturing my daughter to stay out of the tanning beds. so those of us on these meds.. MTX and NSAIDS..... are screwed.. because it's ill advised to expose yourself to tanning ... I'm becoming even more interested in this Steroid/Vitamin D thing.  My mom was put on D by her doc, some huge amount.  I talked her out of it...so I thought.  She was taking one of the huge caps instead of both.  Anyway, the doc called her and told her to stop taking the D as she went sky high on her numbers after her last blood draw.  She admitted to him she was only taking half and they told her to stop it all then.  Blue skin can also be caused by colloid silver. Is she drinking that?The other thing...Is her skin blue from cyanosis? That is a whole different story.Pip, what kind of numbers are we talking about? I mean, what are her labs measuring that the doctor thought the Vitamin D caused them to go sky high?Lori - no the doc told her it was from her meds.  And she doesn't do the silver thing.  I understand the logic behind it...but that scares me. Well, why did the doc put her on D in the first place? And what's she taking mino for?

Discolouration from mino usually manifests on the leg. I do have a scar on my arm that turned blue from mino, though. I had a blackberry bush scratch that I got a lot of sun on this summer and so it tuned a purply blue, but since then it's faded a lot and I suspect it will eventually go away.[QUOTE=babs10]so those of us on these meds.. MTX and NSAIDS..... are screwed.. because it's ill advised to expose yourself to tanning ... [/QUOTE]