AI diseases have genetic overlap | Arthritis Information
Well, I always said all these AI diseases were different manifestations of the same thing:
No sh*t, SherlockFrom article:
This resulted in a study of 11 immune-related diseases. It appears that 23 genes are involved in at least two immune-related diseases; each of these 23 genes is associated with at least two diseases. In addition, further research revealed that the function of these genes overlaps.
Does this mean that we have a high chance of developing a 2nd autoimmune disease before we die?YEP!Do I get to pick? Just for the record, genetic predisposition and infection theory don't cancel each other out. Something triggers the genes, be it infection, vitamin d, stress, or any other theoretical trigger.I've already gotten a second AI disease... am I done now?
crap.. I have to agree w/ Gimpy again!! There are triggers... as you say........... that start this up..
(Now I have the Stones running through my head: Start me UP!!
If you start it up
Kick on the starter give it all you got, you got, you got
I can't compete with the riders in the other heats
If you rough it up
If you like it you can slide it up, slide it up
If you start me up
If you start me up I'll never stop
If you start me up
If you start me up I'll never stop
I've been running hot
You got me ticking gonna blow my top
If you start me up
If you start me up I'll never stop
I obviously have a strong genetic predisposition for RA, as my father had RA and another AI disease..... my father too, Lynn and gout.. mom had Raynauds and died from hodgkins lymphoma complications (infection of encephalitis and broken hip) ... my maternal grandmother had RA as well... maternal great-grandmother had type 2 diabetes.... we don't know as much about dad's side of the family since most were west and we never saw them.[QUOTE=Gimpy-a-gogo]Just for the record, genetic predisposition and infection theory don't cancel each other out. Something triggers the genes, be it infection, vitamin d, stress, or any other theoretical trigger.[/QUOTE]
that's why you have to approach researching this thing from all directions
Ive got at least 3.. can I quit now?
[QUOTE=buckeye][QUOTE=Gimpy-a-gogo]Just for the record, genetic predisposition and infection theory don't cancel each other out. Something triggers the genes, be it infection, vitamin d, stress, or any other theoretical trigger.[/QUOTE]
that's why you have to approach researching this thing from all directions
[/QUOTE]
Wise words buckeye From the article:
Patients with these diseases often have problems with
chronic infections and their immune systems often react against their own tissue.
This often leads to chronic infection reactions in, for example, the joints in the case of rheumatism and the large intestine in the case of Crohn’s disease.
Gimpy - this is from the thread I just started, not this article, but it is my favorite medical moronic explanation of A/I:
The study of mice raises hope that researchers could use the same technique to tackle autoimmune diseases such as rheumatoid arthritis in which the body confuses healthy tissues for foreign substances and attacks itself ...
I get the biggest laff everytime I see this is every article about AI/RA. Right, your immune system for no reason at all suddenly becomes confused and attacks your body, right. Morons. It's the immune system straining beyond its limits trying to contain the mycoplasma infection.
justsaynoemore2009-01-08 18:29:42What's really interesting is that the overlap also tends to be the pathway like with that info found on D receptors.
I still think this all works with gene expression.
I really don't find the idea of cell change all that odd........ I mean. what IS cancer anyway but a mutation of cells and uncontrolled division of those cells..........
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