fermented wheat germ extract for RA? | Arthritis Information

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Has this been posted before?  If so, what did we think?  It seems like I remember something, but I'm not sure.  I think it is interesting - sounds like a natural mtx????

http://www.naturalnews.com/024484.html

How does Avemar work?

Mechanisms of action responsible for Avemar's anti-cancer and immunoregulatory properties include:

* Prevents cancer cell proliferation

* Induces programmed cell death in cancer cells

* Enhances the immune system's ability to target cancerous cells

* Increases recovery rate of immune function following immunosuppressive therapies

* Decreases uptake of glucose by tumor cells

* Promotes balance between cellular and humoral immunity, thus regulating the immune response

This last point refers to one of the most interesting properties of Avemar. In cases of cancer, Avemar stimulates the immune system. In cases of autoimmunity (e.g. rheumatoid arthritis, systemic lupus erythematosus), it offers appropriate immunosuppressive effects. At first glance, this appears contradictory. However, Avemar is able to exert these seemingly opposite effects through its action on different segments of the immune system.

In most cases, cancer therapy complemented with Avemar is proven to be more effective than conventional treatment alone. Avemar not only enhances these treatments, but also reduces their damaging side effects.

Avemar itself has no adverse effects, and shows no toxicity toward normal cells.
Suzanne2009-01-22 13:10:43I found a link to their published trials:

http://www.avemarresearch.com/TOC.html

There's one for you, Pip!  Scroll down to the animal studies - mycoplasma is in there!
Looks interesting, Suzanne.

In Chickens!  LOL  Who tests chickens.

I do like that it didn't spread.
 
This is very intriging Suzanne.  So many people use the denatured whey - I wonder if the denaturing is somehow better for us and somehow converts this into a more useable form?
 
Pip
Here is the (small) RA study:

d) Bálint G, Apáthy A, Gaál M, Telekes A, Resetár A, Blazsó G, Falkay G, Szende B,
Paksy A, Ehrenfeld M, Shoenfeld Y, Hidvégi M., Effect of Avemar--a fermented wheat germ extract--on rheumatoid arthritis. Preliminary data, Clin Exp Rheumatol. 2006 May-Jun;24(3):325-8.
Click to view full text

OBJECTIVE: To investigate the effect of the fermented wheat germ extract (Avemar)in patients with severe rheumatoid arthritis (RA). METHODS: Fifteen female RA (Steinbrocker II-III) patients, who had unsuccessfully tried two different DMARD treatments, were enrolled in an open-label, 1-year long, pilot clinical study. DMARD and steroid therapies were recorded and continued. All patients received Avemar as additional therapy. For measurement of efficacy the Ritchie Index, the Health Assessment Questionnaire (HAQ) and the assessment of morning stiffness were applied. Patients were evaluated at baseline, 6 and 12 months. For statistical analyses the Wilcoxon test was used.RESULTS: At both 6 and 12 months, Ritchie index, HAQ and morning stiffness showed significant improvements compared with the baseline values. Dosages of steroids could be reduced in about half of the patients. No side effects of Avemar were observed. CONCLUSION:Supplementation of standard therapies with a continuous administration of Avemar is beneficial for RA patients.


Is fermented wheat germ extract okay for people with gluten sensitivities?Looks like a 'no', from Avemar site FAQs:

Are there any conditions in which Avemar should not be used and, if so, what are these conditions?
There are some such cases, and they are listed in the in-structions given on the side of the product packaging. The most significant contraindications are the followings:


It's a shame to see pregnancy and nursing, isn't it?  Too bad, there needs to be more options for that


I thought they tested on mice, rats, monkeys, but chickens?  Interesting topic Suzanne, nice find.  I still don't understand it, but its interesting. 
 
Edited to add humans as test subjects. 
justsaynoemore2009-01-22 18:00:08They only did the myco test on chickens.  Maybe they wanted larger organs than mice have?  It does sound weird.

As far as understanding it, all I really follow is that it is gaining mainstream momentum in oncology and they are already seeing that it might help RA - sounds like mtx and others to me.  Without serious side effects.

Myco fighting would be an added bonus, something mtx and others can't claim, right?
Well, I don't think most of the promoters of MTX believe in the mycoplasma connection.Have mycoplasmas ever been tested on chickens?
 
Edited for grammar - I start typing in the singular, move to a plural subject, and drive myself crazy when I miss getting it correct :)
justsaynoemore2009-01-24 13:34:11 [QUOTE=justsaynoemore]Has mycoplasmas ever been tested on chickens? [/QUOTE]

That's a google project for another day LOL.  Would you like the assignment? 

As far as FWGE for RA, someone I respect from another site feels it would be safe to take, but not effective.  They feel it is marketed to look scientific.

That comment was the most interesting to me - studies and trials as marketing tools.


The ole Miranda warning?  Nah, I will leave chicken testing alone, that gives me goosebumps to think about LOL.  [QUOTE=justsaynoemore]Nah, I will leave chicken testing alone, that gives me goosebumps to think about LOL.  [/QUOTE]

Funny you say that - I've been having the opposite problem, thinking about these chickens too much LOL.

I thought about a friend who would not eat chicken for one reason only - chickens eat their own poop, he said.

That made me think of the thread about people who need poop transplants or whatever - remember, to treat c. diff or something?

So then I thought maybe chickens need to eat their poop.  Maybe they self-medicate somehow, because they know they are susceptible to things.  So maybe it was a diabolical plot to study chickens for this purpose.  Maybe they needed self-medicating mycoplasma-ed test subjects to skew the results.  They used mice for the cancer and arthritis studies. 
Lots of animals eat their own (or someone else's) poop, for a variety of reasons.

http://en.wikipedia.org/wiki/Coprophagia

Coprophagia in animals

Two Common Blue butterflies feast on a small lump of feces lying on a rock.

Coprophagous insects consume and redigest the feces of large animals. These feces contain substantial amounts of semi-digested food (herbivores' digestive systems are especially inefficient). The most famous feces-eating insect is the dung-beetle and the most ubiquitous is the fly.

Capybara, rabbits, hamsters and other related species do not have a complex ruminant digestive system. Instead they extract more nutrition from grass by giving their food a second pass through the gut. Soft fecal pellets of partially digested food are excreted and generally consumed immediately. They also produce normal droppings, which are not eaten.

Young elephants, pandas, koalas, and hippos eat the feces of their mother to obtain the bacteria required to properly digest vegetation found on the savanna and in the jungle. When they are born, their intestines do not contain these bacteria (they are completely sterile). Without them, they would be unable to get any nutritional value from plants.

Gorillas eat their own feces and the feces of other gorillas.

Hamsters eat their own droppings, which are thought to be a source of vitamins B and K, produced by bacteria in the gut. Apes have been observed eating horse feces for the salt content. Monkeys have been observed eating elephant feces. Coprophagia also has been observed in the naked mole rat.


[QUOTE=JasmineRain]Lots of animals eat their own (or someone else's) poop, for a variety of reasons.

http://en.wikipedia.org/wiki/Coprophagia

Coprophagia in animals

Two Common Blue butterflies feast on a small lump of feces lying on a rock.

Coprophagous insects consume and redigest the feces of large animals. These feces contain substantial amounts of semi-digested food (herbivores' digestive systems are especially inefficient). The most famous feces-eating insect is the dung-beetle and the most ubiquitous is the fly.

Capybara, rabbits, hamsters and other related species do not have a complex ruminant digestive system. Instead they extract more nutrition from grass by giving their food a second pass through the gut. Soft fecal pellets of partially digested food are excreted and generally consumed immediately. They also produce normal droppings, which are not eaten.

Young elephants, pandas, koalas, and hippos eat the feces of their mother to obtain the bacteria required to properly digest vegetation found on the savanna and in the jungle. When they are born, their intestines do not contain these bacteria (they are completely sterile). Without them, they would be unable to get any nutritional value from plants.

Gorillas eat their own feces and the feces of other gorillas.

Hamsters eat their own droppings, which are thought to be a source of vitamins B and K, produced by bacteria in the gut. Apes have been observed eating horse feces for the salt content. Monkeys have been observed eating elephant feces. Coprophagia also has been observed in the naked mole rat.


[/QUOTE]

But no mention of chickens or mice.  Hmmm....I'm torn..... Diabolical plot to sell safe but ineffective supplement or valid published study with outcome that is above reproach....

Maybe I will contact the researchers and ask if the chickens were permitted to graze freely....
It reads like an ad, and all the "references" are to the website selling the product. [QUOTE=JasmineRain]It reads like an ad, and all the "references" are to the website selling the product. [/QUOTE]

Yes, but I did see that there are other ones out there.  It seemed like Avemar was the first product, and their site had the studies that they say are published.  Didn't Pip post something about 'self publishing'?  Maybe that's the deal.

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