Had to go off of all meds for 4 weeks and I'm in the flair from hell. I've had 2 doses of my MTX now, and 2 doses of Enbrel.....how long do you think that I should be back to my normal self (normal post RA, lol)Hi Deb, I am sorry to hear this, I think in my experience at least with MTX, it really kicks in about week 6, not sure about Enbrel though. Good luck, Janie. Take some pain relief and rest when you can, you know this will improve, so pamper yourself for a while if you can. I hear ya Deb. I was off the MTX for 3 weeks and went into a flare. Then I took it for 2 weeks and did not feel better. Then I had to go off last week again. I took it Tuesday and I am still in a flare. This is my first one so I have no idea but I hope it's soon.Hey Deb, sorry to be the bearer of bad news but my dr. said it could take up to 3 months to get the full benefit of Enbrel (though when I was on it, I felt pretty decent in about 4 weeks). I hope you feel better soon. Could you possibly have a secondary thing like fibromyalgia? It took me a while to determine the difference between the ra flare and the fibro flare. Fibro can make you feel like you have been hit by a truck too.