Remicade allergic shock. What next? | Arthritis Information

Hello again!

This time things are really bad for me since two days ago my daughter had an allergi shock while having her remicade treatment. Thanks God she is better now although terribly shocked. The bad thing is that she cannot go on with it, although she used to take it for 2 years with no problem at all. After her first period with Remicade she was on Humira for 2,5 years and two months ago she switched back to remicade. Although her first new treatment was totally OK, thiw time everything went bad.

She has a flare now which she is trying to control with increased doses of prezolone, methotrextate and some pain relievers. If things go well she will probably pass to Enbrel but for now she is suffering eithout knowing what to do.

Any answers for anyone having a similar experience would be a gift for us

Thank you all

abyfromgreece

How terrible. I'm sure you must feel totally helpless as her mother.

I'm not on Remicade, but was curious about reactions. So I did a little research.

I know it's no consolation, but if it was anaphylactic shock that your daughter experienced, this is an uncommon situation when using Remicade. But it has been reported.

Understand that I am not an MD. Since she's been on this drug before, perhaps it's a simple case of having developed HAHA [human anti-human antibodies] against the drug. Her doctor may have to contact the manufacturer of Remicade [Centocor] and talk with them. They do have some unpublished reports of rare occurrences of reactions, from what I gather.

Is it possible they infused the drug too rapidly? What does her doctor say caused it?

Here are some of the links to the info I came across: http://www.aaaai.org/aadmc/ate/drugreaction.html

http://www.emea.eu.int/pdfs/human/press/pus/003202.pdf

http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp ?documentid=3236

I also read that people who have had reactions [not necessarily to the extent of your daughter's] have safely gone on the drug again afterwards, using a very slow infusion rate and low dose until it can be established that there is no further reaction.

I wish I could be of help to you. Please keep us posted.

Lee

i recently went into shock and passed out during a remicade infusion. i have been getting remicade for just over 3 years with absolutely no bad side effects... so it was a huge disappointment to me. (i'm in my early 50's.) i was about 45 minutes into the infusion when it happened. after a short break, and taking some antihistamine, they continued the infusion very, very slowly.

i will be going back for my next infusion in early january. the plan is to continue with it... i will take prednisone for 2 days prior... and they will infuse me very, very slowly. i am really hoping that all goes well. it has been a miracle drug for me, and i simply will not allow my body to react this way!! i will try to report in after my next infusion. let me know what happens with your daughter next.
-k.

Good for you! Very slow infusion does seem to help, I understand.

We've had a spammer on this board, so most of us have moved over to www.rafriends.com. Please join us there. More support, more people, etc.

Lee