Has anyone have trouble with there eyes watering all the time. I take 20mg predisone could that be it. I went to eye doctor and he said I might have some dry eye but not bad so he gave me some drops for them and they don't help. I wish I was off of the predisone I think that is causing a whole bunch of problems. JoanYES!!! But it's just the left eye and I do have ocular hypertension from long term high dose prednisone. I was told last week though that the pressures in my eyes has gotten down to a very safe level now. Prednisone has caused me nothing but problems as well as now not only do I have the eye thing I mentioned but also high blood pressure, wicked moon face, I've gained a good bit of weight and the thin skin and stretch marks are hell too. Also, I've had hell with recurring sinus and ear infections all winter long.