Treatment of sicca symptoms in Sjögren's syndrome | Arthritis Information

 

Rheumatology, 05/13/09

 

Rihl M et al. – Study demonstrates that hydroxychloroquine (HCQ) treatment led to a beneficial effect on xerostomia in patients with primary Sjögren's syndrome (pSS) who lack severe organ manifestations. The response was greater in α-fodrin-positive patients.

Methods

• Study to evaluate the efficacy of HCQ for glandular function, i.e. saliva and tear production in pSS pts
• Group A (n=14): pts were anti-Ro and/or -La Ab positive except one; were treated with HCQ for up to 6 mo
• Group B (n=21): control group with objective sicca symptoms and positive α-fodrin Ab
• Glandular function was determined by Saxon's and Schirmer's tests for the dominant eye at baseline and at the end of the treatment

Results

• Group A: an increase in saliva production after HCQ treatment
• Particularly the α-fodrin-positive pts responded to HCQ
• Group B: an increase in tear production
• A positive correlation between the α-fodrin IgA Ab concn and the Schirmer's test at baseline and after treatment in this group

http://rheumatology.oxfordjournals.org/cgi/content/abstract/kep104see? I"ve been trying to get my RD to okay a third, DMARD  ala plaq..... You're welcome Babs.  Glad I could be of some help [/QUOTE]

 

I try, though to be honest....Sometimes I wonder why do not give up........ no matter what.....

 

 

[QUOTE=Lynn49][QUOTE=babs10]as always...  a "quality post"  [/QUOTE]
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