Hydroxychloroquine use for pregnant women with AI | Arthritis Information

 

Sperber K et al. – Study provides evidence that hydroxychloroquine (HCQ) is not associated with any increased risk of congenital defects, spontaneous abortions, fetal death, pre-maturity and decreased numbers of live births in patients with auto-immune diseases.

Methods

• Study to compare:
  • Incidence of congenital defects
  • Spontaneous abortions
  • Number of live births
  • Fetal death and pre-maturity
    in women with autoimmune diseases taking HCQ during pregnancy
• MEDLINE, Cochrane data base, Ovid-Currents Clinical Medicine, Ovid-Embase:Drugs and Pharmacology, EBSCO, Web of Science, and SCOPUS literature searches
• All clinical trials identified from 1980 to 2007 regardless of language or publication status
• Cochrane Central Library and www.Clinical trials.gov were also searched

Results

• Odds ratio (OR) of the following events in women taking HCQ during pregnancy were:
  • Congenital defects in live births: 0.66
  • Live birth: 1.05
  • Spontaneous abortion: 0.92
  • Fetal deaths: 0.97
  • Pre-mature birth defined as birth before 37 wks: 1.10
  
  http://www.ped-rheum.com/content/7/1/9

Lynn492009-05-17 06:22:26Bumping this up.HCQ has one of the most extensive "field tests" ever witnessed. It has been, after all, the drug of choice for suppression and treatment of malaria for many years.

CDC: World Malaria Day, April 25 [QUOTE=Lynn49]

Sperber K et al. – Study provides evidence that hydroxychloroquine (HCQ) is not associated with any increased risk of congenital defects, spontaneous abortions, fetal death, pre-maturity and decreased numbers of live births in patients with auto-immune diseases.

[/QUOTE]

This was a major factor in my decision to go with hydroxychloroquine when it was decided that I was going to add a DMARD to the omega-3 EFAs.  Since the husband and I play Vatican Roulette,
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