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I was diagnosed with RA spring of 2009 although I have had the pain for at least 10 years. For some reason my flair ups have been terrible this year and is making it increasingly more difficult to get out of bed in the morning. Its been real hard to come to terms with my diagnoses, but one day at a time I guess

 
My 'diet' consists of:
Methotrexate (10mg) once a week
Plaquanil (200mg) twice a day
Mobic (15mg) once a day
Folic Acid (1mg) once a day
Ultram (100mg or more) once a day
 
I have taken this combination for about 2 months now and aside from the pain meds, I don't really feel any different. My bad days are almost unbearable and interferes with my ability to work. (which is a whole new fear for me now)
 
Is anyone else on a combo of these meds able to tell me approx how long it took to kick in for you.
Hello and welcome to the forum. While everyone responds to DMARDS differently, my personal experience with the combination of MTX and Plaquinel was that it took six months to be effective. Meanwhile, for periodic management of increased stiffness and joint pain my physician would prescribe a burst and taper of corticosteriods/prednisone. Has your physician discussed increasing the MTX dosage? Often, MTX is increased over the course of a few weeks until a dosage is reached where a degree of relief is felt.

I am pleased to meet you, but sorry about the conditions under which the meeting takes place.

Best wishes, Shug

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