Enbrel during pregnancy. | Arthritis Information

 

If anyone here has taken Enbrel during pregnancy or knows someone who has, I would like to talk!  Thanks!

I am looking for the same answers, however it is my husband who is on enbrel and presdnisolone, as we are recently married wondered how/if enbril affects pregnacy/concieving

Thank You

[QUOTE=Foxylady]

I am looking for the same answers, however it is my husband who is on enbrel and presdnisolone, as we are recently married wondered how/if enbril affects pregnacy/concieving

Thank You

[/QUOTE]

I would ask the Rheumy.  I know it is not a problem for women.  The actual drug company will tell you that its safety is unknown, so you should contact the doctor.  Personally, my Rheumy and some of his collegues and important people from schools here and there say it is perfectly fine.  I plan to be on it through conceiving and pregnancy.

These are my links and notes on the subject:  (This includes the info I could find on breastfeeding as well.  I will include it all for future readers.....  some of these links are really good.)  These are just bits and pieces from these pages....

CLICK HERE

CLICK HERE
-Most drugs are safe if:
They are not excreted into the milk. Some drugs are just too big to get into the milk. Examples are heparin, interferon, insulin, infliximab (Remicade), etanercept (Enbrel).”

CLICK HERE
-Is it Enbrel? That's one my derm would be willing to put me on while still nursing. It's not bioavailable orally, so it's really not a bad bet.

-Dr. Hale's website: CLICK HERE There is a medications forum that you can check.

I'm also on Enbrel - my doctor told me that it's ok to be on while ttc/pregnant, and that on the record she can't tell me it's ok to take while nursing, but off the record she would try it herself.
-….brought them to her OB He read over it, and gave her approval to BF!!! He said Enbrel is a class B drug like Tylenol...so it's safe to take while breastfeeding.

CLICK HERE
-“For those interested in nursing, the Enbrel molecule is too big to transfer into breast milk and would be destroyed by the baby's digestive system even if it did.”

CLICK HERE
-I want to give hope to those mothers who are breastfeeding and want to use Enbrel. I did some research with my Pediatrician and the leading breastfeeding research PhD (Dr. David Hale) determined it doesn't pass through breast milk. However, the pharmaceutical company won't ever give that the OK. Too much risk.


CLICK HERE
-Enbrel is FDA category B, but I decided to take advantage of my university setting and tracked down a biochemist. We sat down and discussed Enbrel.
If any of you ever consider using Enbrel in pregnancy, here's what we concluded — your body treats Enbrel like an antibody. There is a blood barrier between you and your baby so that your immune system can't attack the baby. So the Enbrel should not be able to pass through to the baby. And for those interested in nursing, the Enbrel molecule is too big to transfer into breast milk and would be destroyed by the baby's digestive system even if it did.
-I dug this out of the Raptiva U.S. prescribing literature...
Developmental toxicity studies have been performed in rats and rabbits at doses ranging from 60- to 100-fold higher than the human dose and have revealed no evidence of harm to the fetus due to ENBREL.  There are, however, no studies in pregnant women.  Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. (Notice it does not say “never use them.”)

This is a very helpful site for checking safety of Arthritis drugs:

CLICK HERE
-I'm just finishing a study of Remicade which is similar to Enbrel.
No Remicade was found in human milk at all.
I think it safe to use Enbrel or Remicade while breastfeeding.
Both of these are large molecular weight proteins that are not transported, nor penetrate by diffusion, into human milk.
Tom Hale Ph.D.
-Enbrel and Remicade are both antibodies to tumor necrosis factor (TNF) and are large molecular weight IgG monoclonal antibodies. In three breastfeeding patients who have use this product, we found NO Remicade(infliximab) in their milk from 1 hour to 7 days.
Thus I'm not worried at all about its use in breastfeeding mothers.
-Get “Medications and Mothers’ Milk” Tom Hale Ph.D. 2006 12th edition to read the published study

HOPE THIS IS A HELP! 
butterfly38881.79875
Copyright ArthritisInsight.com