UAB researchers discover antibody receptor identity, propose renaming immune-system gene
Previously, researchers who had identified this gene thought they were dealing with a molecule that regulated cell death and they named it "toso" – a reference to the Japanese medicinal sake often drunk on New Year's Day to symbolize a long life. But the toso name is inaccurate, as were many of the earlier descriptions of this gene's function, says Hiromi Kubagawa, M.D., a professor in the UAB Department of Pathology and the lead study author.
"The new study shows, and DNA analysis helped us to confirm, that the Fc mu receptor is made from the gene we describe," Kubagawa says. "This is a fundamental discovery that science has been waiting to answer for nearly 30 years."
To identify the true FCMR gene, the UAB researchers used chronic lymphocytic leukemia cells as a source of this gene, since such leukemia cells are known to over-express the Fc mu receptor. This enabled researchers to identify the FCMR gene more efficiently.
The potential novel agents that target and regulate FCMR function hold promise in fighting cancer, AIDS and autoimmune disorders, says Kubagawa. The genetic description and request for renaming the gene does not prove it has a direct role in any particular disease; however, it fills a crucial gap in understanding the science behind immune deficiencies and allergy diseases.