My mother recently began taking Humira injections for her RA. After the first injection, she seemed to feel a lot better and was doing good. After the second, she started feeling the way she did before taking the first. She has taken four injections so far, and still no improvement. Her Rhuematologist says to take the injections for three months (six injections) before switching to something else. I'm just wondering if anyone else has had a similar reaction to Humira, if it usually takes this long to start working, etc. She is also taking 10mg of Prednisone a day and seven 2.5mg Methotrexate a week. It really does take up to 3 months to see any real results-good or bad. The biologics work on a celular level-takes a while.