I'm newly diagnosed with RA and I've been taking Prednisone and Celebrex for a little over a month now.  I am definitely better but still not at all comfortable.  My doc increased my Prednisone to 10 mg a day, and added MTX 10 mg a week to start. She said I can take up to 2 Celebrex (200mg each) a day but with the side effects, I should try just 1 a day if I can.  
Is there anyone taking 400 mg of Celebrex a day? Any problems with that dose? The info I've read about the risk of heart attacks, strokes, and bleeding has me afraid to take more.  The stiffness is horrible and I can barely sleep at night because of shoulder pain. I guess it's going to take a while for everything to kick in since my RA factor was 281. Thanks. I take 400 mgs of Celebrex and have for I think about 10 yrs now.  So far I haven't had any problems.  Celebrex has really helped with the inflammation.  I take 400 mg. in the am.  and have been for the last 9 years or so with no problems.  LindyI have been taking Celebrex ever since it first became available in Australia (even before it went on our Pharm. Benefits list of part-subsidised meds) as the Naprosyn the rheumy had me on for some years was giving me gut probs and also made my brain feel more like cotton wool.