Canakinumab Tames Gout Flares | Arthritis Information

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BRIGHTON, England -- The monoclonal antibody canakinumab (Ilaris) provided rapid pain relief in acute flares of gout in patients with difficult-to-treat disease, according to results of a randomized trial reported here.

In the month-long trial of 200 gout patients, 78% of those receiving the highest dose of canakinumab achieved 75% or more reduction in pain by 72 hours, and 96% had at least a 50% reduction in pain, according to Alexander So, MD, of the University of Lausanne in Switzerland, and colleagues.

In contrast, only 45% of those assigned to triamcinolone acetonide had a 75% reduction in gout pain by 72 hours and 61% had a 50% reduction, So reported during an oral presentation at the annual meeting of the British Society for Rheumatology here.

 
To read the entire article:
 
http://www.medpagetoday.com/Rheumatology/GeneralRheumatology/25996
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BRIGHTON, England -- The monoclonal antibody canakinumab (Ilaris) provided rapid pain relief in acute flares of gout in patients with difficult-to-treat disease, according to results of a randomized trial reported here.

In the month-long trial of 200 gout patients, 78% of those receiving the highest dose of canakinumab achieved 75% or more reduction in pain by 72 hours, and 96% had at least a 50% reduction in pain, according to Alexander So, MD, of the University of Lausanne in Switzerland, and colleagues.

In contrast, only 45% of those assigned to triamcinolone acetonide had a 75% reduction in gout pain by 72 hours and 61% had a 50% reduction, So reported during an oral presentation at the annual meeting of the British Society for Rheumatology here.
 
To read the entire article:
 
http://www.medpagetoday.com/Rheumatology/GeneralRheumatology/25996
BRIGHTON, England -- The monoclonal antibody canakinumab (Ilaris) provided rapid pain relief in acute flares of gout in patients with difficult-to-treat disease, according to results of a randomized trial reported here.

In the month-long trial of 200 gout patients, 78% of those receiving the highest dose of canakinumab achieved 75% or more reduction in pain by 72 hours, and 96% had at least a 50% reduction in pain, according to Alexander So, MD, of the University of Lausanne in Switzerland, and colleagues.

In contrast, only 45% of those assigned to triamcinolone acetonide had a 75% reduction in gout pain by 72 hours and 61% had a 50% reduction, So reported during an oral presentation at the annual meeting of the British Society for Rheumatology here.
 
To read the entire article:
 
http://www.medpagetoday.com/Rheumatology/GeneralRheumatology/25996
BRIGHTON, England -- The monoclonal antibody canakinumab (Ilaris) provided rapid pain relief in acute flares of gout in patients with difficult-to-treat disease, according to results of a randomized trial reported here.

In the month-long trial of 200 gout patients, 78% of those receiving the highest dose of canakinumab achieved 75% or more reduction in pain by 72 hours, and 96% had at least a 50% reduction in pain, according to Alexander So, MD, of the University of Lausanne in Switzerland, and colleagues.

In contrast, only 45% of those assigned to triamcinolone acetonide had a 75% reduction in gout pain by 72 hours and 61% had a 50% reduction, So reported during an oral presentation at the annual meeting of the British Society for Rheumatology here.
To read the entire article:
BRIGHTON, England -- The monoclonal antibody canakinumab (Ilaris) provided rapid pain relief in acute flares of gout in patients with difficult-to-treat disease, according to results of a randomized trial reported here.

In the month-long trial of 200 gout patients, 78% of those receiving the highest dose of canakinumab achieved 75% or more reduction in pain by 72 hours, and 96% had at least a 50% reduction in pain, according to Alexander So, MD, of the University of Lausanne in Switzerland, and colleagues.

In contrast, only 45% of those assigned to triamcinolone acetonide had a 75% reduction in gout pain by 72 hours and 61% had a 50% reduction, So reported during an oral presentation at the annual meeting of the British Society for Rheumatology here.
 
To read the entire article:
 
http://www.medpagetoday.com/Rheumatology/GeneralRheumatology/25996
 
BRIGHTON, England -- The monoclonal antibody canakinumab (Ilaris) provided rapid pain relief in acute flares of gout in patients with difficult-to-treat disease, according to results of a randomized trial reported here.

In the month-long trial of 200 gout patients, 78% of those receiving the highest dose of canakinumab achieved 75% or more reduction in pain by 72 hours, and 96% had at least a 50% reduction in pain, according to Alexander So, MD, of the University of Lausanne in Switzerland, and colleagues.

In contrast, only 45% of those assigned to triamcinolone acetonide had a 75% reduction in gout pain by 72 hours and 61% had a 50% reduction, So reported during an oral presentation at the annual meeting of the British Society for Rheumatology here.
 
To read the entire article:
 
Lynn492011-05-05 16:26:17 Gout can be controlled by eating and maintaining a healthy diet as follows:

1.  Limit eating foods high in purines especially meat, seafood, and beer.
2.  Eating a healthy diet that provides nutrients you need and helps you control your weight.
3.  Eat low fat dairy products.
4.  Drink plenty of water and other fluids to help the body get rid of uric acid.

Purines are chemical compounds that are broken down into uric acid. High levels of uric acid can cause gout attacks. http://www.arthritisjointpaingone.com

Most purines are made by the body, but some come from foods. Eating foods that have a lot of purines can raise uric acid levels in the body, which may make your gout worse.



Herbs for natural gout treatment focus on underlying causes of gout; which holistic practitioners often view as a lifestyle illness. Any herbal remedy for gout should focus on assisting the break down of crystalline deposits in the body formed by uric acid deposits and reducing the intake of uric acid.

Natural gout treatment is also aimed at treating the cause of gout, including dietary habits that have contributed to this condition and foods that help to relieve gout. Combining diet with a herbal and nutritional approach to improve elimination via the kidneys and liver, and reducing foods known to aggravate gout, is a sensible approach to an easily prevented condition.

The trouble with gout is that there is a great deal of uric acid accumulation in the blood for years on end in many people without any sort of warning or symptoms being produced until an attack is triggered off by some underlying cause. Conventional medications play the most effective actions against an acute attack of gout, which is abrupt in incidence and often occurs without warning. The substance bromelain (found in pineapple) is the supplement of choice to be used during an acute attack of gout. Preventative actions against future attacks can be provided by the other supplements when they are used in tandem. The prolonged and long term utilization of these supplements is very safe and it is suggested that these are used in exactly such a fashion, the best combination of these supplements for long term utilization are a mixture of the extract of the cherry, nettle, the vitamin C. Indeed long-term prevention should be the main goal of the patient.

The anti-inflammatory properties of bromelain may help alleviate some of the pain that comes along with an attack of gout; this substance is a natural enzyme derived from pineapples. The dosage of the bromelain can be decreased and another substance called quercetin can be added to use for long term preventative treatment rather than as a therapeutic measure. The levels of uric acid in the blood are reduced by quercetin, which is a flavonoid; it is added to bromelain because the digestive uptake or absorption of querticin is increased by the bromelain.

Traditional use has been made of the cherries, which can be said to be an old folk remedy for gout, these fruits are very rich in flavonoids, and they can thus reduce the levels of uric acid in the body to a substantial degree, making excellent supplements. Supplementation can be carried out using the extract of the cherry fruits, commonly available at many health-food stores and supermarkets, dosage of the extract can be half a cup each day, the juice of the blueberry is also an excellent substitute if cherries are unavailable. Uric acid can also be freed from the tissues and its rate of excretion via the urine can be increase to a substantial degree through supplementing with incremental doses of the vitamin C. It is best to start using moderate amounts of vitamin C as a supplement, as very high starting doses can remove too much uric acid leading to their crystallization in the kidneys, causing a kidney stone to develop. Topical and external use as well as internal use can be made of another herb, namely the nettle. This herb can be used in the form of capsules to help eliminate and clear out excess uric acid form the tissue spaces. An external use can be made of a tea made form the nettle in hot compresses to alleviate and bring relief to inflamed joints and tissues, whenever an attack of gout occurs.

Certain substances called leukotrienes are involved in the inflammatory reaction during an attack of gout, the oil of the flaxseed can be used to reduce the production of these substances and help deter or reduce the levels of inflammation of tissues. The consumption of natural products such as celery and avocados, and drinking the herbal teas of herbs such as the cat's claw, the devil's claw, or those made from the leaves of the olive are excellent natural ways to bring down the incidence of gout in an individual in the long term as these substances can reduce the production of uric acid in the blood.

http://www.arthritisjointpaingone.com



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