Drugs In Development | Arthritis Information

 

I spoke with the Arthritis Foundation today, and they referred me to this link: http://www.leaddiscovery.co.uk/reports/rheumatoid%20arthriti s.html

I hope this will offer hope to some of you guys that didnt know about this

With all of these drugs in the works, there should be something that will work for each of us (some of these are coming out in 2007):

Drugs in Development for the Treatment of Rheumatoid Arthritis

• Drugs targeting the metabolism of arachidonic acid
  • Cyclooxygenase (COX) Inhibitors
    • Table 1. Selective COX2 inhibitors
  • Drugs targeting other sites of arachidonic acid metabolism
    • Phospholipase A2 Inhibitors
    • Lipoxygenase Inhibitors
    • Variations on NSAIDs
      • Table 2. Drugs in development targeting arachidonate metabolism
• Drugs targeting inflammatory cytokines
  • Biological Inhibitors of cytokines
    • Anti-TNF Monoclonal Antibodies
    • TNF receptors and binding proteins
      • Table 3. Biopharmaceutical approaches to neutralizing TNF
    • Other TNF receptor family members
      • RANK
      • Osteoprotegerin
    • Interleukin-1 antagonists
    • Other cytokine-targeted biologicals
      • Interleukin-6
      • Interleukin-8
      • Interleukin-10
      • Interleukin-12
      • Interleukin-15
      • Interleukin-18
      • Lymphotoxin â
      • B-lymphocyte stimulator
    • Comment
      • Table 4. Biopharmaceutical Products targeting IL-1 and other cytokines
  • New Chemical Entities (NCEs) designed to inhibit cytokines
    • Inhibitors of p38 mitogen activated protein kinase (MAPK)
    • Inhibitors of cytokine activating enzymes
    • Inhibitors of Phosphodiesterase type 4
    • Other approaches to cytokine inhibiting NCEs
      • Table 5. New Chemical Entities (NCEs) targeting cytokine synthesis
• Drugs targeting the movement and activation of inflammatory leukocytes
  • Inhibitors of chemotaxis
    • Antagonists of the complement fraction 5a
    • Chemokine Antagonists
      • Table 6. Drugs targeted at leukocyte chemotaxis
  • Drugs targeting Adhesion Molecules
    • Selectins
    • Lymphocyte Function Antigen-1 (LFA-1, CD11a) antagonists
    • Very Late Antigen-4 (VLA-4) antagonists
      • Table 7. Drugs targeting adhesion molecules
    • Other Adhesion Molecule Targets
• Drugs designed to specifically regulate lymphocyte activation
  • Inhibitors of lymphocyte intracellular enzymes
    • Macrolide immunosuppressants
    • Selective inhibitors of nucleotide metabolism
      • Table 8. Inhibitors of lymphocyte intracellular mechanisms
  • Drugs targeting cell surface receptors on lymphocytes
    • CD2
    • CD3
    • CD4
    • CD20
    • CD25
    • CD40 and CD40 Ligand
    • CD80 (B7)
    • CD152 (CTLA4)
      • Table 9. Biopharmaceuticals targeting lymphocyte cell surface molecules
  • Vaccines and desensitizing agents
    • Table 10. Vaccines and Desensitizing agents
• Anti-proliferative Agents for Rheumatoid Arthritis
  • Table 11. New approaches to anti-proliferatives for rheumatoid arthritis
• Protease Inhibitors
  • Matrix Metalloprotease Inhibitors
  • Elastase Inhibitors
  • Cathepsin Inhibitors
    • Table 12. Protease Inhibitors for Rheumatoid Arthritis
• Anti-angiogenic Agents for Rheumatoid Arthritis
  • Table 13. Anti-Angiogenic Agents
  • Targets for novel anti-angiogenic molecules
    • Growth Factors
    • Cytokines
    • Chemokines
    • Matrix Metalloproteases
    • Plasminogen activators
    • Angiostatic molecules
    • Cell adhesion molecules
• Analgesics for Rheumatoid Arthritis
  • Table 14. Analgesics for Arthritis

some of those are out or were discontinued, but there are others still in the works. The information above was published in 03' but it is good that you are looking for answers and information...thanks for sharing!
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