Enbrel/Humira triggering lupus? | Arthritis Information

Has anyone found that they had RA, then Enbrel/Humira triggered onset of lupus?

Hi, I just found this forum and want to answer your question. In 2005 I was on Humira and developed vasculitis in the retina of my left eye. While the doctors were trying to figure out why I developed that, the blood tests for Lupus came back positive. They tested me for everything under the sun, but the only positive tests were ANA, C4, IgG, and other tests that indicate Lupus. My Rheumy took me off the Humira and 6 months later my tests turned negative. Surprisingly she redid the tests last month and they are positive again, but the titer isn't as high. So she's not sure what I have. I've always been told I have seronegative RA and Sjorgrens, but now she's thinking to add Lupus to that.

Did this happen to you?

Donna

Hello from a newbie!

Hi out there. I wanted to introduce myself to everyone. I’ve been searching the web for info about lupus and found this board. I’ve never thought about joining a board before, but after reading through some posts, I’m happy I did. I just want to say thanks to everyone for the support you offer here

Great lupus video

I found this site called realhealth.tv which has a great video. Even though I am a new member, I think everyone here would really like watching this film b/c it was really nice hearing and watching someone talk about their difficulties and how they cope. I wanted to share this with everyone here, hoping it would help you guys too. Here's the link http http://www.realhealth.tv/site.html?goto=31&vid=34&vo =0

I have PA not RA and I've been on Humira for 2 years in May. I recently
had blood work done that showed a huge ANA titre (1:1240??). I know its
non-specific but it had never been high before. My former rheumy used
to test me for it because my sister has lupus.

I was just diagnosed with blood clots in my lungs and both legs. It turns
out I have lupus anticoagulant in my blood. This doesn't mine I have
lupus because about 1/2 the people with LA don't have lupus.

Anyway, while I was feeling sick and before I found out about the LA and
high ANA, I was perusing various websites and I saw something about
Humiria increasing ANA titres and that this was reversible. It must have
been listed as a side effect of Humira.

Anwyay, this might be revelant in both of our cases.

I haven't asked my doctor yet, but I will.

Tell me what you find out.

Jennifer

Hi all,

My Boyfriend's father has lupus and they are trying Humira on him experimentally. Seeing the replies here that it can TRIGGER lupus makes me very uneasy! What are your thoughts. Should he get a new doctor?

I should say, his doctor THINKS he has lupus (after years of not being able to figure out what it is) the Titer showed elevated levels.Both Enbrel and Humira are known to cause lupus type syndrome. I think the lupus like symptoms disappear after discontinuing Enbrel.

No, but I had been on all of them before getting a huge blood clot in the lungs. I am always told I have a high lupus count. but that my dx is RA (severe). I would not be surprised if it did trigger lupus. but not just the biologics, all of the ra meds. before I was treated for RA, my flares were months apart. and symptoms only appeared with the flares. after being treated for RA the symptoms became everyday and the flares more intense. at the present time rd are doing what they think is best but I am sure the way ra is treated will change eventually.