I have been taking methotrexate for 6 months and have barely felt any relief.
My doctor tells me to be patient. I also take indomethacin(sp?). I am at a
point where i can't tell if the indomethacin is this only thing remotely dulling
the pain. Previously i had been taking an older anti-inflammatory called
piroxicam. That and as much tylenol as i felt comfortable injesting. I
essentially feel the same. My question is how long?? Injectables are very
expensive and I find my self wanting to slam down a six pack out of
frustration. Of course i don't do this. I'm also paranoid about my liver
beacause i found out enzyme tests are not conclusive. IS methotrexate the
"gold standard" for treating psoriatic arthritis?? Does anyone use anything
to combat liver damage aside from folic acid? I forgot to add one important
point: I take 6 -2.5 mg tablets of methotrexate a week. I'm told this is a
small dose.
There's people that post in the RA listing that have PA. Some of the people here have more than one kind of arthritis. I don't have PA, at least not to date, so I can't help much with that.
I did however take MTX for about 18yrs. Several times I had to stop taking it for a short while because my liver enzymes were too elevated. As soon as my blood work came back ok I was back on the MTX again. The only thing people seem to take is the folic acid to protect the liver. A number of people who take Enbrel also take MTX. MTX stopped working for me so I take Imuran instead.
Welcome to our forum. See you around.
Barb
P.S. Check out the postings under ridges in nails
Let me add my experience I started taking MTX by injection in 1995-I had pleuritis which is inflammation of the lining of the lung, caused by the PA. That hurts like you know what. I mention that because I am a med rebel and resist most chemical intervention, but hey, you do what you have to do. It did work. It put me in remission. I took it for five years but I hated, I mean HATED the side effects: nausea, constant tiredness, stupidhead syndrome. I stopped it in 2000-and remain in remission. Actually I'm kind of borderline remission right now. But there is hope, THERE IS ALWAYS HOPE. The weird thing about arthritis is you never know when it's just going to go away. I have the kind of PA that gets you all over: knees, ankles, toes, shoulders, wrists, knuckles, hip...you name it. One gets to form an intimate relationship with pain when they have this disease. It's just kind of around all the time. Back to the MTX: Folic Acid is the bomb when you are on the regiment. Don't ever not take it. And as far the liver, I would advise not to dwell on that. If you are on the MTX you probably don't have a choice. Just keep up w/ your folic acid and do not engage in any other activities that can harm your liver, most importantly I think: DO NOT DRINK ALCOHOL. Not even a little bit. It's just not worth the chance. On a hopeful not, after my five years I suffered NO Liver damage. Just be aware. Lastly I will say, although I really HATE MTX , it does the job. I think back to 30 years ago when the only recourse were even more evil drugs that really didn't stop the progression of the disease (ie gold, prednisone) A friend of mine's mother had this disease, diagnosed in the 70's and was very crippled. Because of MTX and other advancements in treatment we are blessed with the opportunity to avoid that fate. Keep up the good fight, B Hi, I'm new to this board but do participate in one called LupusOz (Australia). I found you guys by searching for info on PA...something my Lupus has thrown up as another challenge for me for the past 18 or so months. Am interested to hear people's experiences with mtx. My Rheumy says that's an option if the symptoms become overwhelming. I don't want to go on it so am toughing it out on Plaquenil and NSAIDS. Thankfully the Plaq has the symptoms under control but my ankles/feet are killing me by the end of the day. I've been on Imuran for other Lupus things and did go into remission then for about 6 years actually. I'd love to think the mtx could bring about remission...I am an optimist
The few posts that I've read haven't mentioned Plaquenil. I'm presuming that this drug is prescribed in the U.S. too. Anyway, I look forward to chatting in the future and I'll read your posts with interest. Someone was talking about plaquenil, i was on that for a while too, but didn't notice anything, i was actually on that for a really long time, i think its when she put me on MTX that she took me off plaquenil.
working for you. I don't think i've heard of imuran. I get the feeling my
doctor thinks i'm overly paranoid about the risk of liver damage. I have a
hard time with the vagueness of the stuff. I suppose they protect themselves
by introducing a warning regarding possible "side affects". The next stage
for me ... more pills probably. If i only had the psoriasis i would at least have
homeopathic remedies and acupuncture and not be enslaved to drug
companies. Oh well.
best regards
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