feeling pretty good today | Arthritis Information

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better than normal. course i know that could change in an hour. but today my dose of desipramine goes from one to two. for three days, then i up it to 3 per day there after.

it does seem to dbe helping me cope with the pain. i know its there, but i feel like i can embrace it rather than hate it. sounds kinda strange, but i joke with Gwen about it saying, i love my pain, where would i be with out it?

its my way of coping. this stuff is helping my attitude at least. even if the pain it still there.

i've been keeping a log, 4 days straight now

never been much for that, but my pcp says that helps me and them when it comes time to talk again. so i am trying to stick to it. if i dont have the time in the morning, i always carry it with me and i log during the day how i am feeling and where i hurt.

i'm off to the dentist for some more pain

 

i just cant get enough!

 

Great to hear you're having a good day, Harold! Have fun at the
dentist.

Hi Harold. What's despramine?

I'm glad you're having a good day too. I've been trying to figure out why I feel so much better today. I had a stressful, tiring day yesterday and today is rotten weather. Rules say I should feel worse today. Go figure.

Harold,  I wish I could do a select all on this message board as this is where I keep my log.  Then just a copy and paste.  I am too tired after posting to write it down for myself and I need that feedback.

Glad you had a good day today![QUOTE=RKGal]

Hi Harold. What's despramine?

I'm glad you're having a good day too. I've been trying to figure out why I feel so much better today. I had a stressful, tiring day yesterday and today is rotten weather. Rules say I should feel worse today. Go figure.

[/QUOTE]

Desipramine

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Desipramine
Systematic (IUPAC) name
 ?
Identifiers
CAS number 50-47-5
ATC code N06AA01
PubChem 2995
DrugBank APRD00022
Chemical data
Formula C18H22N2
Mol. weight 266.381
Pharmacokinetic data
Bioavailability 73-92%
Metabolism Hepatic
Half life 21-23 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status

Rx only

Routes oral

Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin® and Pertofrane®. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine.

Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect.


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