can you tell that MTX is wearing off? | Arthritis Information

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Perhaps it's in my head, but I take my MTX on Thursday nights and about Tuesday night or Wednesday morning I feel like crap.  I didn't really notice this until It was pointed out to me by a friend.  Wednesday's seem to be a "bad" day and I'm wondering if it is because my MTX is due?

Am I nuts? LOL you are not nuts.  What you are experiencing happens to a lot of us.  Not everyone...but some of us.  I know that the day before I am due for my shot is harder than other days.  I can't wait for my shot the next day!  Then it's all ahhhhhhh.  I would rather be waiting on that shot for one day than have no good days at all!I also know the day before med day, sometimes 2 days before.me too. not so much that I need it, but boy if I dont take it on friday afternoon, I am sure aware saturday ..

I guess this proves that the MTX is starting to help me.  It really didn't happen until I upped the dose to 20 mg.  I guess that's good news, huh?  LOL

Thanks for writing back.  It's so nice to hear from people with experience.

Dear dk, you aren't nuts and I think like you do 'hey this must be working'....I've been known to take my pills in 6 days , instead of 7, that is the good part about pills you can 'adjust' them to your needs. Sarah We can play with our injection days by maybe a day or 2.  I have done a day early when I have been super bad before. 

I can definately tell. I always take mine on Saturday's and toward the end of the week I start to get run down.

It's not in your head.

I can really tell too.  I take mine in Friday evening and I start huting on thursday, and think 'oh no-why is this hurtings/' then realize it's almost Friday. so it will be fine. 
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